Evidence map›Paper›PMID 38585977›Full record

ArticlebioRxiv : the preprint server for biology2024

LeGenD: determining N-glycoprofiles using an explainable AI-leveraged model with lectin profiling.

Haining Li, Angelo G Peralta, Sanne Schoffelen, Anders Holmgaard Hansen, Johnny Arnsdorf, Song-Min Schinn, Jonathan Skidmore, Biswa Choudhury, Mousumi Paulchakrabarti, Bjorn G Voldborg and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Haining LiDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Angelo G PeraltaDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-4774-0906
Sanne SchoffelenNational Biologics Facility Department of Biotechnology and Biomedicine, Technical University of Denmark, Building 220, Kemitorvet, 2800 Kgs. Lyngby Denmark.
Anders Holmgaard HansenNational Biologics Facility Department of Biotechnology and Biomedicine, Technical University of Denmark, Building 220, Kemitorvet, 2800 Kgs. Lyngby Denmark.ORCID 0000-0002-6007-4787
Johnny ArnsdorfNational Biologics Facility Department of Biotechnology and Biomedicine, Technical University of Denmark, Building 220, Kemitorvet, 2800 Kgs. Lyngby Denmark.
Song-Min SchinnDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Jonathan SkidmoreDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Biswa ChoudhuryGlycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093, USA.
Mousumi PaulchakrabartiGlycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093, USA.
Bjorn G VoldborgNational Biologics Facility Department of Biotechnology and Biomedicine, Technical University of Denmark, Building 220, Kemitorvet, 2800 Kgs. Lyngby Denmark.
Austin W T ChiangDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
Nathan E LewisDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
University of California San Diego · USTechnical University of Denmark · DKBrigham Young University · US

Funding

Unraveling the mammalian secretory pathway through systems biology and algorithm developmentR35GM119850 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LEWIS, NATHAN ENOCH · 2016 to 2025
$4.3M
NIGMS NIH HHS R35 GM119850
6 · The paper itself

Abstract

Glycosylation affects many vital functions of organisms. Therefore, its surveillance is critical from basic science to biotechnology, including biopharmaceutical development and clinical diagnostics. However, conventional glycan structure analysis faces challenges with throughput and cost. Lectins offer an alternative approach for analyzing glycans, but they only provide glycan epitopes and not full glycan structure information. To overcome these limitations, we developed LeGenD, a lectin and AI-based approach to predict

Identifiers

PMID38585977
PMCPMC10996628
OpenAlexW4393338852

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.