ArticleResearch square2024
Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration.
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Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
68 authors at 20 institutions in 8 countries.
Rowan SalonerUniversity of California, San Francisco.ORCID 0000-0002-1351-6183
Adam StaffaroniUniversity of California, San Francisco.ORCID 0000-0002-3903-9805
Eric DammerEmory University.ORCID 000-0003-2947-7606
Erik C B JohnsonEmory University School of Medicine.ORCID 0000-0002-0604-2944
Emily PaolilloUniversity of California, San Francisco.
Amy WiseUniversity of California, San Francisco.
Hilary HeuerUniversity of California, San Francisco.
Leah ForsbergMayo Clinic.
Argentina Lario LagoUniversity of California, San Francisco.
Julia WebbUniversity of California, San Francisco.
Jacob VogelLund University.
Alexander SantilloLund University.
Oskar HanssonLund University.ORCID 0000-0001-8467-7286
Joel KramerUniversity of California, San Francisco.
Bruce MillerUniversity of California San Francisco.
Jingyao LiNovartis Institutes for Biomedical Research, Inc.
Joseph Loureiro
Rajeev SivasankaranNovartis Institutes for Biomedical Research.ORCID 0000-0003-3917-0181
Kathleen WorringerNovartis (United States).
Nicholas SeyfriedEmory University School of Medicine.ORCID 000-0002-4507-624X
Jennifer YokoyamaUCSF.ORCID 0000-0001-7274-2634
William SeeleyUniversity of California at San Francisco.
Salvatore SpinaUniversity of California, San Francisco.ORCID 0000-0003-3570-9143
Lea GrinbergUniversity of California at San Francisco.ORCID 0000-0002-6809-0618
Lawren VandeVredeUniversity of California, San Francisco.ORCID 0000-0002-8304-6711
Peter LjubenkovUniversity of California, San Francisco.
Ece BayramUniversity of California, San Diego.
Andrea BozokiUniversity of North Carolina.
Danielle BrushaberMayo Clinic.ORCID 0009-0007-0543-0228
Ciaran ConsidineVanderbilt University.
Gregory DayMayo Clinic in Florida.ORCID 0000-0001-5133-5538
Bradford DickersonHarvard University.ORCID 0000-0002-5958-3445
Kimiko Domoto-ReillyUniversity of Washington.ORCID 0000-0002-7396-1633
Kelley FaberIndiana University.
Douglas GalaskoUC San Diego.ORCID 0000-0001-6195-3241
Daniel GeschwindUCLA Health System and David Geffen School of Medicine.ORCID 0000-0003-2896-3450
Nupur GhoshalWashington University.ORCID 0000-0002-6680-6731
Neill Graff-RadfordMayo Clinic.
Chadwick HalesEmory University.
Lawrence HonigColumbia University.ORCID 0000-0002-9703-2265
Ging-Yuek HsiungUniversity of British Columbia.ORCID 0000-0002-8017-0856
Edward HueyColumbia University.
John KornakUniversity of California, San Francisco.
Walter KremersMayo Clinic.
Maria LapidMayo Clinic.ORCID 0000-0002-1163-5584
Suzee LeeUniversity of California, San Francisco.
Irene LitvanUCSD.ORCID 0000-0002-3485-3445
Corey McMillanDepartment of Neurology, University of Pennsylvania, Philadelphia, USA.
Mario MendezORCID 0000-0001-6441-7989
Toji MiyagawaMayo Clinic.
Alexander PantelyatJohns Hopkins University.
Belen PascualHouston Methodist.ORCID 0000-0002-4467-7406
Henry PaulsonUniversity of Michigan-Ann Arbor.
Leonard PetrucelliMayo Clinic.
Peter PressmanUniversity of Colorado.
Eliana RamosUniversity of California, Los Angeles.
Katya RascovskyUniversity of California, San Francisco.
Erik RobersonUniversity of Alabama at Birmingham.ORCID 0000-0002-1810-9763
Rodolfo SavicaMayo Clinic.
Allison SnyderNational Institutes of Health.ORCID 0000-0002-1857-928X
A Campbell SullivanUniversity of Texas Health San Antonio.
Carmela TartagliaUniversity of Toronto.ORCID 0000-0002-5944-8497
Marijne VandeberghUniversity of Antwerp.ORCID 0000-0001-9645-2615
Bradley BoeveMayo Clinic.ORCID 0000-0002-4153-8187
Howie RosenUniversity of California, San Francisco.
Julio RojasUniversity of California, San Francisco.
Adam BoxerMemory and Aging Center, Department of Neurology, University of California, San Francisco.
Kaitlin CasalettoUniversity of California, San Francisco.
University of California, San Francisco · USWinnMed · USEmory University · USLund University · SEColumbia University · USNovartis (Switzerland) · CHHarvard University Press · USHouston Methodist · USIndiana University · USJohns Hopkins University · USMayo Clinic in Florida · USNational Institutes of Health · USNovartis (United States) · USThe University of Texas Health Science Center at San Antonio · USUCLA Health · USUC San Diego Health System · USUniversidad Católica de Santa Fe · ARUniversidad Católica Santo Domingo · DOUniversity of Alabama at Birmingham · USUniversity of Antwerp · BE
Funding
Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI Bradley F Boeve · 2019 to 2026
$120.9MNational Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MNATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8MTDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MResearch Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9MUCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DOUGLAS R GALASKO · 2019 to 2026
$34.9MThe Four Repeat Tauopathy Neuroimaging InitiativeR01AG038791 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2010 to 2020
$18.1MLongitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)U01AG045390 · NIA · MAYO CLINIC ROCHESTER · PI BOEVE, BRADLEY F, ROSEN, HOWARD J · 2014 to 2018
$16.9MDementia with Lewy Bodies Consortium - Supplement for ASL sequenceU01NS100610 · NINDS · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI DOUGLAS R GALASKO, JAMES Bruce LEVERENZ · 2016 to 2026
$15.6MClinical Coordination Center for STEADY-PD3U01NS080818 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SIMUNI, TANYA · 2014 to 2018
$13.0MThe Frontotemporal Lobar Degeneration Neuroimaging InitiativeR01AG032306 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSEN, HOWARD J · 2009 to 2013
$10.0MMechanisms of Executive Decline in Normal AgingR01AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaitlin B Casaletto, JOEL H KRAMER · 2009 to 2026
$8.3MNIA NIH HHS K23 AG059888NIA NIH HHS K23 AG059891NIA NIH HHS K23 AG061253NIA NIH HHS K23 AG073514NIA NIH HHS K24 AG045333NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG062429NIA NIH HHS R01 AG032289NIA NIH HHS R01 AG032306NIA NIH HHS R01 AG038791NIA NIH HHS R01 AG048234NIA NIH HHS R01 AG058233NIA NIH HHS R01 AG062268NIA NIH HHS R01 AG072475NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG045390NIA NIH HHS U01 AG079850NIA NIH HHS U19 AG063911NIA NIH HHS U24 AG021886NIMH NIH HHS R01 MH120794NINDS NIH HHS R21 NS114764NINDS NIH HHS R25 NS098999NINDS NIH HHS U01 NS080818NINDS NIH HHS U01 NS100610NINDS NIH HHS U01 NS102035NINDS NIH HHS U54 NS092089
Abstract
The pathophysiological mechanisms driving disease progression of frontotemporal lobar degeneration (FTLD) and corresponding biomarkers are not fully understood. We leveraged aptamer-based proteomics (> 4,000 proteins) to identify dysregulated communities of co-expressed cerebrospinal fluid proteins in 116 adults carrying autosomal dominant FTLD mutations (
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