Evidence map›Paper›PMID 38585966›Full record

ArticlebioRxiv : the preprint server for biology2024

Tumor Stroma Content Regulates Penetration and Efficacy of Tumor-targeting Bacteria.

Y Zhan, B Burkel, E J Leaman, S M Ponik, B Behkam

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Y ZhanDepartment of Mechanical Engineering, Virginia Tech, Blacksburg, VA, USA.
B BurkelDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, USA.
E J LeamanDepartment of Mechanical Engineering, Virginia Tech, Blacksburg, VA, USA.ORCID 0000-0002-0241-6400
S M PonikDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0003-1367-4349
B BehkamDepartment of Mechanical Engineering, Virginia Tech, Blacksburg, VA, USA.
Virginia Tech · USUniversity of Wisconsin–Madison · US

Funding

TECH CoreU54CA268069 · NCI · UNIVERSITY OF MINNESOTA · PI Kevin William Eliceiri, Paolo Provenzano · 2022 to 2026
$8.2M
Matrix density promotes pro-tumorigenic hormone actions in breast cancerR01CA179556 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI PONIK, SUZANNE MARIE, SCHULER, LINDA A. · 2014 to 2024
$4.9M
NCI NIH HHS R01 CA179556NCI NIH HHS U54 CA268069
6 · The paper itself

Abstract

Bacteria-based cancer therapy (BBCT) strains grow selectively in primary tumors and metastases, colonize solid tumors independent of genetics, and kill cells resistant to standard molecular therapy. Clinical trials of BBCT in solid tumors have not reported any survival advantage yet, partly due to the limited bacterial colonization. Collagen, abundant in primary and metastatic solid tumors, has a well-known role in hindering intratumoral penetration of therapeutics. Nevertheless, the effect of collagen content on the intratumoral penetration and antitumor efficacy of BBCT is rarely unexplored. We hypothesized that the presence of collagen limits the penetration and, thereby, the antitumor effects of tumor-selective

Identifiers

PMID38585966
PMCPMC10996712
OpenAlexW4393355210

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.