Evidence map›Paper›PMID 38585951›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Rapid Biphasic Decay of Intact and Defective HIV DNA Reservoir During Acute Treated HIV Disease.

Alton Barbehenn, Lei Shi, Junzhe Shao, Rebecca Hoh, Heather M Hartig, Vivian Pae, Sannidhi Sarvadhavabhatla, Sophia Donaire, Caroline Sheikhzadeh, Jeffrey Milush and 16 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 4 institutions in 1 country.

Alton BarbehennDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA 94110, USA.ORCID 0009-0000-3364-7204
Lei ShiDepartment of Biostatistics, University of California Berkeley, Berkeley, CA 94110, USA.
Junzhe ShaoDepartment of Biostatistics, University of California Berkeley, Berkeley, CA 94110, USA.
Rebecca HohDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA 94110, USA.
Heather M HartigDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA 94110, USA.
Vivian PaeDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA 94110, USA.
Sannidhi SarvadhavabhatlaDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA 94110, USA.
Sophia DonaireDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA 94110, USA.
Caroline SheikhzadehDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA 94110, USA.
Jeffrey MilushDepartment of Medicine, Division of Experimental Medicine, University of California San Francisco, San Francisco, CA 94110, USA.
Gregory M LairdAccelevirDiagnostics, Baltimore, MD 21202, USA.
Mignot MathiasAccelevirDiagnostics, Baltimore, MD 21202, USA.
Kristen RitterAccelevirDiagnostics, Baltimore, MD 21202, USA.
Michael J PelusoDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA 94110, USA.
Jeffrey MartinDepartment of Biostatistics & Epidemiology, University of California San Francisco, CA 94158, USA.
Frederick HechtDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA 94110, USA.
Christopher PilcherDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA 94110, USA.
Stephanie E CohenDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA 94110, USA.
Susan BuchbinderSan Francisco Department of Public Health, San Francisco, CA 94102, USA.
Diane HavlirDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA 94110, USA.
Monica GandhiDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA 94110, USA.
Timothy J HenrichDepartment of Medicine, Division of Experimental Medicine, University of California San Francisco, San Francisco, CA 94110, USA.
Hiroyu HatanoDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA 94110, USA.
Jingshen WangDepartment of Biostatistics, University of California Berkeley, Berkeley, CA 94110, USA.
Steven G DeeksDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA 94110, USA.
Sulggi A LeeDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA 94110, USA.
University of California, San Francisco · USUniversity of California, Berkeley · USVPDiagnostics (United States) · USSan Francisco Department of Public Health · US

Funding

Delaney AIDS Research Enterprise to Cure HIVUM1AI164560 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS, Sharon Ruth Lewin · 2021 to 2026
$32.0M
Centralized Resource to Accurately Quantify Latent and Expressed HIV ReservoirsU24AI143502 · NIAID · ACCELEVIR DIAGNOSTICS, LLC · PI LAIRD, GREGORY MICHAEL, MARTIN, ALBINE · 2020 to 2024
$4.9M
Centralized Resource to Accurately Quantify Latent and Expressed HIVReservoirsR24AI143502 · NIAID · ACCELEVIR DIAGNOSTICS, LLC · PI Gregory Michael Laird, Albine Martin · 2025 to 2026
$2.1M
A pharmacogenomics study of HIV latency: the role of PD-1 signalingK23GM112526 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, SULGGI ANGELA · 2014 to 2018
$908k
NIAID NIH HHS R24 AI143502NIAID NIH HHS U24 AI143502NIAID NIH HHS UM1 AI164560NIGMS NIH HHS K23 GM112526
6 · The paper itself

Abstract

Despite antiretroviral therapy (ART), HIV persists in latently-infected cells ("the reservoir") which decay slowly over time. Here, leveraging >500 longitudinal samples from 67 people with HIV (PWH) treated during acute infection, we developed a novel mathematical model to predict reservoir decay from peripheral CD4+ T cells. Nonlinear generalized additive models demonstrated rapid biphasic decay of intact DNA (week 0-5: t

Indexed as

acute HIVantiretroviral therapy (ART)HIV reservoir decaypre-exposure prophylaxis (PrEP)

Identifiers

PMID38585951
PMCPMC10996734
OpenAlexW4393253471

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.