Evidence map›Paper›PMID 38585934›Full record

ArticlebioRxiv : the preprint server for biology2024

Pharmacological stimulation of infralimbic cortex after fear conditioning facilitates subsequent fear extinction.

Hugo Bayer, James E Hassell, Cecily R Oleksiak, Gabriela M Garcia, Hollis L Vaughan, Vitor A L Juliano, Stephen Maren

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Hugo BayerDepartment of Psychological and Brain Sciences, Texas A&M University, College Station.ORCID 0000-0002-0611-9454
James E HassellDepartment of Psychological and Brain Sciences, Texas A&M University, College Station.ORCID 0000-0002-8336-4875
Cecily R OleksiakDepartment of Psychological and Brain Sciences, Texas A&M University, College Station.ORCID 0000-0001-5363-3467
Gabriela M GarciaDepartment of Psychological and Brain Sciences, Texas A&M University, College Station.
Hollis L VaughanDepartment of Psychological and Brain Sciences, Texas A&M University, College Station.
Vitor A L JulianoDepartment of Psychological and Brain Sciences, Texas A&M University, College Station.ORCID 0000-0003-2180-2398
Stephen MarenDepartment of Psychological and Brain Sciences, Texas A&M University, College Station.ORCID 0000-0002-9342-7411
Mitchell Institute · USUniversidade de São Paulo · BR

Funding

Neural Substrates of Contextual Memory in Fear ExtinctionR01MH065961 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MAREN, STEPHEN · 2003 to 2025
$7.9M
Neural Circuits for Stress-Impaired Extinction LearningR01MH117852 · NIMH · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Stephen Maren · 2018 to 2026
$4.6M
NIMH NIH HHS R01 MH065961NIMH NIH HHS R01 MH117852
6 · The paper itself

Abstract

The infralimbic (IL) division of the medial prefrontal cortex (mPFC) is a crucial site for extinction of conditioned fear memories in rodents. Recent work suggests that neuronal plasticity in the IL that occurs during (or soon after) fear conditioning enables subsequent IL-dependent extinction learning. We therefore hypothesized that pharmacological activation of the IL after fear conditioning would promote the extinction of conditioned fear. To test this hypothesis, we characterized the effects of post-conditioning infusions of the GABA

Identifiers

PMID38585934
PMCPMC10996553
OpenAlexW4393220194

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.