Evidence map›Paper›PMID 38585898›Full record

ArticlebioRxiv : the preprint server for biology2024

Differences in polygenic associations with educational attainment between West and East Germany before and after reunification.

D Fraemke, Y E Willems, A Okbay, G Wagner, E M Tucker-Drob, K P Harden, R Hertwig, P Koellinger, L Raffington

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

D FraemkeMax Planck Research Group Biosocial - Biology, Social Disparities, and Development; Max Planck Institute for Human Development; Lentzeallee 94, 14195 Berlin, Germany.ORCID 0009-0007-3446-9367
Y E WillemsMax Planck Research Group Biosocial - Biology, Social Disparities, and Development; Max Planck Institute for Human Development; Lentzeallee 94, 14195 Berlin, Germany.ORCID 0000-0002-5747-0164
A OkbaySchool of Business and Economics, Economics Fellow, Tinbergen Institute, Amsterdam.
G WagnerMax Planck Institute for Human Development, Berlin.
E M Tucker-DrobDepartment of Psychology, The University of Texas, Austin.
K P HardenDepartment of Psychology, The University of Texas, Austin.
R HertwigMax Planck Institute for Human Development, Berlin.
P KoellingerSchool of Business and Economics, Economics Fellow, Tinbergen Institute, Amsterdam.
L RaffingtonMax Planck Research Group Biosocial - Biology, Social Disparities, and Development; Max Planck Institute for Human Development; Lentzeallee 94, 14195 Berlin, Germany.ORCID 0000-0002-0144-5605

Funding

Program Development and Pilot CoreP30AG066614 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI KAREN L FINGERMAN · 2020 to 2026
$5.2M
Scientific & Technical CoreP2CHD042849 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI MARK D. HAYWARD · 2017 to 2026
$5.2M
Dissecting the Multivariate Genetic Architecture of Psychiatric DiseasesR01MH120219 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI NIVARD, MICHEL GUILLAUME, TUCKER-DROB, ELLIOT MAX · 2020 to 2024
$3.3M
Cortisol, Socioeconomic Status, and Genetic Influences on Cognitive DevelopmentR01HD083613 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI TUCKER-DROB, ELLIOT MAX · 2016 to 2020
$3.0M
Environmental, Genetic, and Epigenetic Mechanisms for Hormonal ChangeR01HD092548 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI HARDEN, KATHRYN PAIGE · 2019 to 2023
$3.0M
Large-Scale Genomic Analysis of Aging-Related Cognitive Change Prior to Dementia OnsetRF1AG073593 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI TUCKER-DROB, ELLIOT MAX · 2021 to 2021
$2.1M
NIA NIH HHS P30 AG066614NIA NIH HHS RF1 AG073593NICHD NIH HHS P2C HD042849NICHD NIH HHS R01 HD083613NICHD NIH HHS R01 HD092548NIMH NIH HHS R01 MH120219
6 · The paper itself

Abstract

Here we examine geographical and historical differences in polygenic associations with educational attainment in East and West Germany around reunification. We test this in n = 1902 25-85-year-olds from the German SOEP-G[ene] cohort. We leverage a DNA-based measure of genetic influence, a polygenic index calculated based on a previous genome-wide association study of educational attainment in individuals living in democratic countries. We find that polygenic associations with educational attainment were significantly stronger among East, but not West, Germans after but not before reunification. Negative control analyses of a polygenic index of height with educational attainment and height indicate that this gene-by-environemt interaction is specific to the educational domain. These findings suggest that the shift from an East German state-socialist to a free-market West German system increased the importance of genetic variants previously identified as important for education.

Indexed as

EducationGene-environment interactionGeneticsGerman reunification

Identifiers

PMID38585898
PMCPMC10996480

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.