Evidence map›Paper›PMID 38585891›Full record

ArticlebioRxiv : the preprint server for biology2024

Spinal motoneuron excitability is homeostatically-regulated through β-adrenergic neuromodulation in wild-type and presymptomatic SOD1 mice.

Stefano Antonucci, Guillaume Caron, Natalie Dikwella, Sruthi Sankari Krishnamurty, Anthony Harster, Hina Zarrin, Aboud Tahanis, Florian Olde Heuvel, Simon M Danner, Albert C Ludolph and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 5 countries.

Stefano AntonucciDept. of Neurology, Ulm University, Ulm, DE.
Guillaume CaronUniversité Paris Cité, CNRS, Saints-Pères Paris Institute for the Neurosciences, Paris, France.
Natalie DikwellaDept. of Neurology, Ulm University, Ulm, DE.
Sruthi Sankari KrishnamurtyDept. of Neurology, Ulm University, Ulm, DE.
Anthony HarsterUniversité Paris Cité, CNRS, Saints-Pères Paris Institute for the Neurosciences, Paris, France.
Hina ZarrinDept. of Neurology, Ulm University, Ulm, DE.
Aboud TahanisDept. of Neurology, Ulm University, Ulm, DE.
Florian Olde HeuvelDept. of Neurology, Ulm University, Ulm, DE.
Simon M DannerDepartment of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, United States.ORCID 0000-0002-4642-7064
Albert C LudolphDept. of Neurology, Ulm University, Ulm, DE.
Kamil GryczDept. of Neurobiology, Poznań University of Physical Education, Poland.
Marcin BączykDept. of Neurobiology, Poznań University of Physical Education, Poland.
Daniel ZytnickiUniversité Paris Cité, CNRS, Saints-Pères Paris Institute for the Neurosciences, Paris, France.
Francesco RoselliDept. of Neurology, Ulm University, Ulm, DE.
New Ulm Medical Center · USCentre National de la Recherche Scientifique · FRUniversity School of Physical Education in Kraków · PLDrexel University · USUniversität Ulm · DE

Funding

Propriopsinal neuron function in normal and post-SCI locomotionR01NS112304 · NINDS · UNIVERSITY OF LOUISVILLE · PI Simon Michael Danner, David SK Magnuson · 2021 to 2026
$3.0M
Motoneuron mortality in neurodegenerative diseases induced by homeostatic dysregulation of excitabilityR01NS110953 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BINDER, MARC D, HECKMAN, CHARLES · 2019 to 2023
$2.8M
Spinal circuits for sensorimotor integration and interlimb coordination during locomotionR01NS115900 · NINDS · DREXEL UNIVERSITY · PI DANNER, SIMON MICHAEL · 2020 to 2024
$1.7M
NINDS NIH HHS R01 NS110953NINDS NIH HHS R01 NS112304NINDS NIH HHS R01 NS115900
6 · The paper itself

Abstract

Homeostatic feedback loops are essential to stabilize the activity of neurons and neuronal networks. It has been hypothesized that, in the context of Amyotrophic Lateral Sclerosis (ALS), an excessive gain in feedback loops might hyper- or hypo-excite motoneurons (MNs) and contribute to the pathogenesis. Here, we investigated how the neuromodulation of MN intrinsic properties is homeostatically controlled in presymptomatic adult SOD1(G93A) mice and in the age-matched control WT mice. First, we determined that β2 and β3- adrenergic receptors, which are Gs-coupled receptors and subject to tight and robust feedback loops, are specifically expressed in spinal MNs of both SOD1 and WT mice at P45. We then demonstrated that these receptors elicit a so-far overlooked neuromodulation of the firing and excitability properties of MNs. These electrical properties are homeostatically regulated following receptor engagement, which triggers ion channel transcriptional changes and downregulates those receptors. These homeostatic feedbacks are not dysregulated in presymptomatic SOD1 mice, and they set the MN excitability upon β-adrenergic neuromodulation.

Indexed as

Amyotrophic Lateral SclerosischannelomeGPCRhomeostatic feedbacksin vivo intracellular electrophysiologySpinal motoneuronstranscriptomicsβ-adrenergic neuromodulation

Identifiers

PMID38585891
PMCPMC10996613
OpenAlexW4393305100

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.