Evidence map›Paper›PMID 38585880›Full record

ArticlebioRxiv : the preprint server for biology2024

Nucleic Acid Aptamers Protect Against Lead (Pb(II)) Toxicity.

Afreen Anwar, Solimar Ramis De Ayreflor Reyes, Aijaz Ahmad John, Erik Breiling, Abigail M O'Connor, Stephanie Reis, Jae-Hyuck Shim, Ali Asghar Shah, Jagan Srinivasan, Natalie G Farny

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Afreen AnwarDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, 01609, USA.
Solimar Ramis De Ayreflor ReyesDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, 01609, USA.
Aijaz Ahmad JohnDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Erik BreilingDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, 01609, USA.
Abigail M O'ConnorDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, 01609, USA.
Stephanie ReisDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, 01609, USA.
Jae-Hyuck ShimDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-4947-3293
Ali Asghar ShahDepartment of Biotechnology, Baba Ghulam Shah Badshah University, Rajouri (J&K), India.ORCID 0000-0002-1492-9617
Jagan SrinivasanDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, 01609, USA.ORCID 0000-0001-5449-7938
Natalie G FarnyDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, 01609, USA.ORCID 0000-0003-1143-4560
Worcester Polytechnic Institute · USUniversity of Massachusetts Chan Medical School · USBaba Ghulam Shah Badshah University · IN

Funding

Identification of novel regulators governing osteoclast-osteoblast couplingR01AR068983 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI SHIM, JAE-HYUCK · 2016 to 2020
$1.9M
Novel approach to promote bone formation in osteoporosis using bone-homing mesenchymal stem cellsR21AR073331 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI SHIM, JAE-HYUCK, TUNG, CHING-HSUAN · 2018 to 2019
$425k
NIAMS NIH HHS R01 AR068983NIAMS NIH HHS R21 AR073331
6 · The paper itself

Abstract

Lead (Pb(II)) is a pervasive heavy metal toxin with many well-established negative effects on human health. Lead toxicity arises from cumulative, repeated environmental exposures. Thus, prophylactic strategies to protect against the bioaccumulation of lead could reduce lead-associated human pathologies. Here we show that DNA and RNA aptamers protect

Indexed as

aptamerbehaviorC. elegansLeadneurotoxicityosteoblastPb(II)reproductive toxicity

Identifiers

PMID38585880
PMCPMC10996642
OpenAlexW4393363253

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.