Evidence map›Paper›PMID 38585866›Full record

ArticlebioRxiv : the preprint server for biology2025

Challenges and Efficacy of Astrocyte-to-Neuron Reprogramming in Spinal Cord Injury: In Vitro Insights and In Vivo Outcomes.

Alessia Niceforo, Lyandysha V Zholudeva, Silvia Fernandes, Yashvi Shah, Michael A Lane, Liang Qiang

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alessia NiceforoDepartment of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA, 19129, USA.ORCID 0009-0004-9044-666X
Lyandysha V ZholudevaGladstone Institutes, San Francisco, California, 94158, USA.ORCID 0000-0003-4995-8466
Silvia FernandesDepartment of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA, 19129, USA.
Yashvi ShahCollege of Medicine, Drexel University, Philadelphia, PA, 19104, USA.
Michael A LaneDepartment of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA, 19129, USA.
Liang QiangDepartment of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA, 19129, USA.ORCID 0000-0001-9896-602X
Drexel University · USGladstone Institutes · US

Funding

Neural transplants to promote respiratory plasticity after spinal cord injuryR01NS104291 · NINDS · DREXEL UNIVERSITY · PI LANE, MICHAEL ARON · 2018 to 2022
$1.7M
Engineering Human Interneurons for Neural RepairF32NS119348 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI ZHOLUDEVA, LYANDYSHA VIKTOROVNA · 2021 to 2022
$91k
NINDS NIH HHS F32 NS119348NINDS NIH HHS R01 NS104291
6 · The paper itself

Abstract

Traumatic spinal cord injury (SCI) leads to the disruption of neural pathways, causing loss of neural cells, with subsequent reactive gliosis and tissue scarring that limit endogenous repair. One potential therapeutic strategy to address this is to target reactive scar-forming astrocytes with direct cellular reprogramming to convert them into neurons, by overexpression of neurogenic transcription factors. Here we used lentiviral constructs to overexpress

Indexed as

astrocyteiPS cellsneuronreprogrammingspinal cord injurytranscription factor

Identifiers

PMID38585866
PMCPMC10996511
OpenAlexW4393319475

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.