Evidence map›Paper›PMID 38585850›Full record

ArticlebioRxiv : the preprint server for biology2024

Macromolecular interactions and geometrical confinement determine the 3D diffusion of ribosome-sized particles in live

Diana Valverde-Mendez, Alp M Sunol, Benjamin P Bratton, Morgan Delarue, Jennifer L Hofmann, Joseph P Sheehan, Zemer Gitai, Liam J Holt, Joshua W Shaevitz, Roseanna N Zia

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 11 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Diana Valverde-MendezDepartment of Physics, Princeton University, Princeton, NJ 08540, USA.ORCID 0000-0002-1350-4991
Alp M SunolDepartment of Chemical Engineering, Stanford University, , Stanford, CA 94305, USA.ORCID 0000-0002-6768-4019
Benjamin P BrattonLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA.ORCID 0000-0003-1128-2560
Morgan DelarueLAAS-CNRS, Université de Toulouse, CNRS, Toulouse, France.ORCID 0000-0003-1114-298X
Jennifer L HofmannDepartment of Chemical Engineering, Stanford University, , Stanford, CA 94305, USA.ORCID 0000-0003-2799-3172
Joseph P SheehanDepartment of Molecular Biology, Princeton University, Princeton, NJ 08540, USA.ORCID 0000-0001-9431-7110
Zemer GitaiDepartment of Molecular Biology, Princeton University, Princeton, NJ 08540, USA.ORCID 0000-0002-3280-6178
Liam J HoltInstitute for Systems Genetics, New York University School of Medicine, 435 E 30th St, NY 10016, USA.ORCID 0000-0002-4002-0861
Joshua W ShaevitzDepartment of Physics, Princeton University, Princeton, NJ 08540, USA.ORCID 0000-0001-8809-4723
Roseanna N ZiaDepartment of Chemical Engineering, Stanford University, , Stanford, CA 94305, USA.ORCID 0000-0002-2763-9811
Princeton University · USCentre National de la Recherche Scientifique · FRHarvard University Press · USInstitute for Systems Biology · USStanford University · USUniversity of Missouri · USVanderbilt University · US

Funding

The Physical Biology of Neurodegeneration in Sporadic Amyotrophic Lateral Sclerosis/Frontotemporal DementiaR01NS127186 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HOLT, LIAM J, PHATNANI, HEMALI · 2021 to 2025
$8.2M
Cancer under pressure: Mechanisms of adaptation to compressive stressR37CA240765 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HOLT, LIAM J · 2019 to 2025
$3.2M
Tools to probe the biophysical properties of cellsR01GM132447 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HOLT, LIAM J · 2019 to 2022
$2.1M
NCI NIH HHS R37 CA240765NIGMS NIH HHS R01 GM132447NINDS NIH HHS R01 NS127186
6 · The paper itself

Abstract

The crowded bacterial cytoplasm is comprised of biomolecules that span several orders of magnitude in size and electrical charge. This complexity has been proposed as the source of the rich spatial organization and apparent anomalous diffusion of intracellular components, although this has not been tested directly. Here, we use biplane microscopy to track the 3D motion of self-assembled bacterial Genetically Encoded Multimeric nanoparticles (bGEMs) with tunable size (20 to 50 nm) and charge (-2160 to +1800 e) in live

Indexed as

anomalous diffusionbacterial cytoplasmbiophysicsmicrobiology

Identifiers

PMID38585850
PMCPMC10996671
OpenAlexW4393261734

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.