Evidence map›Paper›PMID 38585849›Full record

ArticlemedRxiv : the preprint server for health sciences2024

The Burden of Cancer and Pre-cancerous Conditions Among Transgender Individuals in a Large Healthcare Network.

Shuang Yang, Yongqiu Li, Christopher W Wheldon, Mattia Prosperi, Thomas J George, Elizabeth A Shenkman, Fei Wang, Jiang Bian, Yi Guo

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Shuang YangDepartment of Health Outcomes and Biomedical Informatics, University of Florida, Gainesville, Florida, USA.
Yongqiu LiDepartment of Health Outcomes and Biomedical Informatics, University of Florida, Gainesville, Florida, USA.
Christopher W WheldonDepartment of Social and Behavioral Sciences, Temple University, Philadelphia, Pennsylvania, USA.
Mattia ProsperiDepartment of Epidemiology, University of Florida, Gainesville, Florida, USA.
Thomas J GeorgeDivision of Hematology and Oncology, University of Florida, Gainesville, Florida, USA.
Elizabeth A ShenkmanDepartment of Health Outcomes and Biomedical Informatics, University of Florida, Gainesville, Florida, USA.
Fei WangDepartment of Population Health Sciences, Weill Cornell Medicine, New York, New York, USA.
Jiang BianDepartment of Health Outcomes and Biomedical Informatics, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-2238-5429
Yi GuoDepartment of Health Outcomes and Biomedical Informatics, University of Florida, Gainesville, Florida, USA.
University of Florida Health · USUniversity of Florida · USCornell University · USTemple College · US

Funding

Disparities of Alzheimer's disease progression in Sexual Minority IndividualsR01AG080624 · NIA · UNIVERSITY OF FLORIDA · PI Jiang Bian, Yi Guo · 2023 to 2026
$3.1M
The benefits and harms of lung cancer screening in FloridaR01CA246418 · NCI · UNIVERSITY OF FLORIDA · PI BIAN, JIANG, GUO, YI · 2020 to 2023
$1.7M
Using Electronic Health Records from a Large Clinical Data Research Network to Understand Cancer Burden and Cancer Risks Among Transgender and Gender Nonconforming (TGNC) IndividualsR21CA245858 · NCI · UNIVERSITY OF FLORIDA · PI BIAN, JIANG, GUO, YI · 2020 to 2021
$773k
Optimizing the Population Representativeness of Older Adults in Alzheimer's Disease and Related Dementia Clinical TrialsR21AG068717 · NIA · UNIVERSITY OF FLORIDA · PI BIAN, JIANG, GUO, YI · 2020 to 2021
$419k
Optimizing the Population Representativeness of Older Adults in Cancer TrialsR21CA253394 · NCI · UNIVERSITY OF FLORIDA · PI BIAN, JIANG, GUO, YI · 2021 to 2021
$392k
NCI NIH HHS R01 CA246418NCI NIH HHS R21 CA245858NCI NIH HHS R21 CA253394NIA NIH HHS R01 AG080624NIA NIH HHS R21 AG068717
6 · The paper itself

Abstract

The current study aimed to examine the prevalence of and risk factors for cancer and pre-cancerous conditions, comparing transgender and cisgender individuals, using 2012-2023 electronic health record data from a large healthcare system. We identified 2,745 transgender individuals using a previously validated computable phenotype and 54,900 matched cisgender individuals. We calculated the prevalence of cancer and pre-cancer related to human papillomavirus (HPV), human immunodeficiency virus (HIV), tobacco, alcohol, lung, breast, colorectum, and built multivariable logistic models to examine the association between gender identity and the presence of cancer or pre-cancer. Results indicated similar odds of developing cancer across gender identities, but transgender individuals exhibited significantly higher risks for pre-cancerous conditions, including alcohol-related, breast, and colorectal pre-cancers compared to cisgender women, and HPV-related, tobacco-related, alcohol-related, and colorectal pre-cancers compared to cisgender men. These findings underscore the need for tailored interventions and policies addressing cancer health disparities affecting the transgender population.

Identifiers

PMID38585849
PMCPMC10996763
OpenAlexW4393201973

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.