Evidence map›Paper›PMID 38585829›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Whole genome sequencing and transmission analysis of

Shaoming Xiao, Ahmed Abade, Waqo Boru, Watipaso Kasambara, John Mwaba, Francis Ongole, Mariam Mmanywa, Nídia Sequeira Trovão, Roma Chilengi, Geoffrey Kwenda and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Shaoming XiaoDivision of Pediatric Infectious Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-8842-8209
Ahmed AbadeMinistry of Health, Dar es Salaam, Tanzania.
Waqo BoruField Epidemiology and Laboratory Training Program, Nairobi, Kenya.
Watipaso KasambaraMinistry of Health, Lilongwe, Malawi.
John MwabaCenter for Infectious Disease Research, Zambia.
Francis OngoleMinistry of Health, Kampala, Uganda.
Mariam MmanywaMinistry of Health, Dar es Salaam, Tanzania.
Nídia Sequeira TrovãoFogarty International Center, National Institute of Health, Bethesda, MD, USA.ORCID 0000-0002-2106-1166
Roma ChilengiZambia National Public Health Institute, Lusaka, Zambia.
Geoffrey KwendaDepartment of Biomedical Sciences, School of Health Sciences, University of Zambia, Lusaka, Zambia.
Christopher Garimoi OrachMinistry of Health, Kampala, Uganda.
Innocent ChibweMinistry of Health, Lilongwe, Malawi.
Godfrey BwireMinistry of Health, Kampala, Uganda.
O Colin StineUniversity of Maryland School of Medicine, Baltimore, USA.
Aaron M MilstoneDivision of Pediatric Infectious Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Justin LesslerDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-9741-8109
Andrew S AzmanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0001-8662-9077
Wensheng LuoDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Kelsey MurtDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
David A SackDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Amanda K DebesDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Shirlee WohlDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-0311-3348

Funding

Epidemiology and Ecology of Cholera in AfricaR01AI123422 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Amanda Kay Debes, DAVID A SACK · 2017 to 2026
$6.6M
Respiratory Culture Stewardship to Reduce Antibiotic Use in Critically Ill ChildrenR01HS028634 · AHRQ · JOHNS HOPKINS UNIVERSITY · PI AARON M MILSTONE · 2022 to 2026
$2.3M
Mentoring in prevention of hospital-acquired infections and antibiotic resistanceK24AI141580 · NIAID · JOHNS HOPKINS UNIVERSITY · PI AARON M MILSTONE · 2019 to 2026
$1.4M
AHRQ HHS R01 HS028634NIAID NIH HHS K24 AI141580NIAID NIH HHS R01 AI123422
6 · The paper itself

Abstract

Background: Despite ongoing containment and vaccination efforts, cholera remains prevalent in many countries in sub-Saharan Africa. Part of the difficulty in containing cholera comes from our lack of understanding of how it circulates throughout the region, so this study uses genomic epidemiology to identify disease transmission patterns in Southern and Eastern Africa. Methods: To better characterize regional transmission, we performed whole genome sequencing on 142 Findings: We showed that Interpretations: Our findings suggest that previously identified sporadic cases may be from larger, undersampled outbreaks, highlighting the need for careful examination of sampling biases and underscoring the need for continued and expanded cholera surveillance across the African continent.

Identifiers

PMID38585829
PMCPMC10996759

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.