Evidence map›Paper›PMID 38585793›Full record

ArticlebioRxiv : the preprint server for biology2024

Gag proteins encoded by endogenous retroviruses are required for zebrafish development.

Ni-Chen Chang, Jonathan N Wells, Andrew Y Wang, Phillip Schofield, Yi-Chia Huang, Vinh H Truong, Marcos Simoes-Costa, Cédric Feschotte

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ni-Chen ChangDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.ORCID 0000-0002-9948-7634
Jonathan N WellsDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.ORCID 0000-0003-3700-020X
Andrew Y WangDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.
Phillip SchofieldDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.ORCID 0000-0002-9318-2725
Yi-Chia HuangDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-8028-532X
Vinh H TruongDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.
Marcos Simoes-CostaDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Cédric FeschotteDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.ORCID 0000-0002-8772-6976
Cornell University · USBoston Children's Hospital · US

Funding

Genomic and Physiological Impact of Transposable Elements.R35GM122550 · NIGMS · CORNELL UNIVERSITY · PI Cedric Feschotte · 2017 to 2026
$4.4M
NIGMS NIH HHS R35 GM122550
6 · The paper itself

Abstract

Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound of TE-derived sequences repurposed for organismal function. The process by which TEs become coopted remains obscure because most cases involve ancient, transpositionally inactive elements. Reports of active TEs serving beneficial functions are scarce and often contentious due to difficulties in manipulating repetitive sequences. Here we show that recently active TEs in zebrafish encode products critical for embryonic development. Knockdown and rescue experiments demonstrate that the endogenous retrovirus family BHIKHARI-1 (Bik-1) encodes a Gag protein essential for mesoderm development. Mechanistically, Bik-1 Gag associates with the cell membrane and its ectopic expression in chicken embryos alters cell migration. Similarly, depletion of BHIKHARI-2 Gag, a relative of Bik-1, causes defects in neural crest development in zebrafish. We propose an "addiction" model to explain how active TEs can be integrated into conserved developmental processes.

Identifiers

PMID38585793
PMCPMC10996621
OpenAlexW4393182890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.