Evidence map›Paper›PMID 38585782›Full record

ArticlebioRxiv : the preprint server for biology2024

Ablation of Mitochondrial RCC1-L Induces Nigral Dopaminergic Neurodegeneration and Parkinsonian-like Motor Symptoms.

Kaylin J Ellioff, Susan M K Osting, Alyssa Lentine, Ashley D Welper, Corinna Burger, Daniel S Greenspan

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kaylin J EllioffDepartment of Neurology, University of Wisconsin, Madison WI, 53706.
Susan M K OstingDepartment of Neurology, University of Wisconsin, Madison WI, 53706.
Alyssa LentineDepartment of Cell and Regenerative Biology, University of Wisconsin, Madison WI, 53705.
Ashley D WelperDepartment of Cell and Regenerative Biology, University of Wisconsin, Madison WI, 53705.
Corinna BurgerDepartment of Neurology, University of Wisconsin, Madison WI, 53706.ORCID 0000-0002-9432-0114
Daniel S GreenspanDepartment of Cell and Regenerative Biology, University of Wisconsin, Madison WI, 53705.
University of Wisconsin–Madison · US

Funding

The fetal-umbilical connection: role of hypoblast/visceral endodermR01HD079481 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI GREENSPAN, DANIEL S · 2014 to 2018
$1.5M
NICHD NIH HHS R01 HD079481
6 · The paper itself

Abstract

Mitochondrial dysfunction has been linked to both idiopathic and familial forms of Parkinson's disease (PD). We have previously identified RCC1-like (RCC1L) as a protein of the inner mitochondrial membrane important to mitochondrial fusion. Herein, to test whether deficits in RCC1L mitochondrial function might be involved in PD pathology, we have selectively ablated the

Indexed as

dopaminergic neuronmitochondrial fusionmitoribosomeNeurodegenerationParkinson’s diseaseRCC1Lstriatumsubstantia nigraWBCR16

Identifiers

PMID38585782
PMCPMC10996473
OpenAlexW4389304035

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.