Evidence map›Paper›PMID 38585739›Full record

ArticlebioRxiv : the preprint server for biology2024

An Innovative Mitochondrial-targeted Gene Therapy for Cancer Treatment.

Kai Chen, Patrick Ernst, Seulhee Kim, Yingnan Si, Tanvi Varadkar, Matthew D Ringel, Xiaoguang Margaret Liu, Lufang Zhou

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kai ChenDepartment of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA.
Patrick ErnstDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Seulhee KimDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
Yingnan SiDepartment of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA.
Tanvi VaradkarDepartment of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA.
Matthew D RingelDepartment of Molecular Medicine and Therapeutics, The Ohio State University, Columbus, Ohio, USA.
Xiaoguang Margaret LiuDepartment of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA.
Lufang ZhouDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
The Ohio State University · USUniversity of Alabama at Birmingham · US

Funding

Combine mitochondrial gene therapy and synthetic lethal chemotherapy to treat triple-negative breast cancerR01CA262028 · NCI · OHIO STATE UNIVERSITY · PI Xiaoguang Margaret Liu, Eddy Shih Hsin Yang · 2022 to 2026
$2.8M
Synergistic Targeted Therapy of Antibody-Drug Conjugates for Triple-Negative Breast CancerR01CA238273 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LIU, RUNHUA RUNA, LIU, XIAOGUANG MARGARET · 2020 to 2025
$2.4M
Delineate the Pathophysiological Effect of Cardiomyocyte-specific Mitochondrial StressR01HL156581 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHOU, LUFANG · 2021 to 2025
$2.2M
Role of p21-activated kinases in thyroid cancerR01CA227847 · NCI · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2018 to 2022
$1.9M
NCI NIH HHS R01 CA227847NCI NIH HHS R01 CA238273NCI NIH HHS R01 CA262028NHLBI NIH HHS R01 HL156581
6 · The paper itself

Abstract

Targeting cancer cell mitochondria holds great therapeutic promise, yet current strategies to specifically and effectively destroy cancer mitochondria

Identifiers

PMID38585739
PMCPMC10996521
OpenAlexW4393247156

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.