Evidence map›Paper›PMID 38585737›Full record

ArticlebioRxiv : the preprint server for biology2024

Predictive modeling provides insight into the clinical heterogeneity associated with

Rebecca Meyer-Schuman, Allison R Cale, Jennifer A Pierluissi, Kira E Jonatzke, Young N Park, Guy M Lenk, Stephanie N Oprescu, Marina A Grachtchouk, Andrzej A Dlugosz, Asim A Beg and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Rebecca Meyer-SchumanDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Allison R CaleDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Jennifer A PierluissiDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Kira E JonatzkeDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Young N ParkDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Guy M LenkDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Stephanie N OprescuDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Marina A GrachtchoukDepartment of Dermatology, University of Michigan, Ann Arbor, MI, USA.
Andrzej A DlugoszDepartment of Dermatology, University of Michigan, Ann Arbor, MI, USA.
Asim A BegNeuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA.
Miriam H MeislerDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Anthony AntonellisDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.
University of Michigan · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
PREDOCTORAL TRAINING IN GENETICST32GM007544 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 1985 to 2022
$11.3M
INSERTIONAL MUTANTS AND DEVELOPMENT IN TRANSGENIC MICER01GM024872 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MEISLER, MIRIAM H · 1985 to 2024
$10.7M
University of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Johann Eli Gudjonsson · 2019 to 2026
$6.6M
Defining the Role of Aminoacyl-tRNA Synthetases in Human Health and DiseaseR35GM136441 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Anthony Antonellis · 2020 to 2026
$2.8M
Defining the Molecular Pathology of Neuropathy-associated Aminoacyl-tRNA Synthetase MutationsF31NS108510 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHUMAN, REBECCA MEYER · 2018 to 2020
$74k
NCI NIH HHS P30 CA046592NIAMS NIH HHS P30 AR075043NIGMS NIH HHS R01 GM024872NIGMS NIH HHS R35 GM136441NIGMS NIH HHS T32 GM007544NINDS NIH HHS F31 NS108510
6 · The paper itself

Abstract

Aminoacyl-tRNA synthetases (ARSs) are ubiquitously expressed, essential enzymes that complete the first step of protein translation: ligation of amino acids to cognate tRNAs. Genes encoding ARSs have been implicated in myriad dominant and recessive phenotypes, the latter often affecting multiple tissues but with frequent involvement of the central and peripheral nervous system, liver, and lungs. Threonyl-tRNA synthetase (

Identifiers

PMID38585737
PMCPMC10996635
OpenAlexW4393276682

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.