Evidence map›Paper›PMID 38585715›Full record

ArticleResearch square2024

Ultra-fast genetically encoded sensor for precise real-time monitoring of physiological and pathophysiological peroxide dynamics.

Andre Berndt, Justin Lee, Woojin Won, Kandace Kimball, Carlie Neiswanger, Selena Schattauer, Yihan Wang, Fred Yeboah, Micaela Ruiz, Kira Evitts and 8 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 2 countries.

Andre BerndtUniversity of Washington.ORCID 0000-0003-4758-5598
Justin LeeUniversity of Washington.ORCID 0000-0002-0284-2389
Woojin WonInstitute for Basic Science.
Kandace KimballUniversity of Washington.
Carlie NeiswangerUniversity of Washington.
Selena SchattauerUniversity of Washington.
Yihan WangUniversity of Washington.
Fred YeboahUniversity of Washington.
Micaela RuizUniversity of Washington.
Kira EvittsUniversity of Washington.
Michael RappleyeUniversity of Washington.ORCID 0000-0002-2885-3406
Samantha BremnerUniversity of Washington.
Changho ChunUniversity of Washington.
Netta SmithUniversity of Washington.
David MackUniversity of Washington.ORCID 0000-0003-1340-7056
Jessica YoungUniversity of Washington.
C Justin LeeIBS (Institute for Basic Science).ORCID 0000-0002-3555-0980
Charles ChavkinUniversity of Washington.
University of Washington · USInstitute for Basic Science · KR

Funding

University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI Charles Chavkin · 2019 to 2026
$13.0M
TRAINING IN THE MOLECULAR PHARMACOLOGY OF ABUSED DRUGST32DA007278 · NIDA · UNIVERSITY OF WASHINGTON · PI Susan Marie Ferguson, Paul E. M. Phillips · 1993 to 2026
$9.8M
Biological Mechanisms of Healthy Aging Training GrantT32AG066574 · NIA · UNIVERSITY OF WASHINGTON · PI David J. Marcinek, Jessica E Young · 2020 to 2026
$5.3M
Next Generation Opto-GPCRs for Neuromodulatory ControlU01NS128537 · NINDS · UNIVERSITY OF WASHINGTON · PI Andre Berndt, Michael R. Bruchas · 2023 to 2026
$4.4M
High-throughput engineering of ligand-selective fluorescent biosensors for detecting endogenous and exogenous opioidsRF1MH130391 · NIMH · UNIVERSITY OF WASHINGTON · PI BERNDT, ANDRE, BRUCHAS, MICHAEL R. · 2023 to 2023
$2.5M
Structure-guided and high-throughput engineering of genetically encoded sensors for reactive oxygen speciesR01GM139850 · NIGMS · UNIVERSITY OF WASHINGTON · PI BERNDT, ANDRE · 2021 to 2024
$1.6M
In vivo real-time monitoring of reactive oxygen species and opioid signaling in a model for opioid receptor activity.R21DA051193 · NIDA · UNIVERSITY OF WASHINGTON · PI BERNDT, ANDRE · 2021 to 2022
$461k
Deciphering biased agonistic activation of mu-opioid receptor by novel optogenetic hydrogen peroxide sensorF31DA056121 · NIDA · UNIVERSITY OF WASHINGTON · PI LEE, JUSTIN · 2022 to 2024
$85k
NIA NIH HHS T32 AG066574NIDA NIH HHS F31 DA056121NIDA NIH HHS P30 DA048736NIDA NIH HHS R21 DA051193NIDA NIH HHS T32 DA007278NIGMS NIH HHS R01 GM139850NIMH NIH HHS RF1 MH130391NINDS NIH HHS U01 NS128537
6 · The paper itself

Abstract

Hydrogen Peroxide (H

Identifiers

PMID38585715
PMCPMC10996778
OpenAlexW4393160034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.