Evidence map›Paper›PMID 38585371›Full record

ArticlePhysics and imaging in radiation oncology2024

Intra-fractional geometric and dose/volume metric variations of magnetic resonance imaging-guided stereotactic radiotherapy of prostate bed after radical prostatectomy.

Yu Gao, Stephanie Yoon, Ting Martin Ma, Yingli Yang, Ke Sheng, Daniel A Low, Leslie Ballas, Michael L Steinberg, Amar U Kishan, Minsong Cao

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In one paragraph

Article in Physics and imaging in radiation oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yu GaoDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, USA.
Stephanie YoonDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, USA.
Ting Martin MaDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, USA.
Yingli YangDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, USA.
Ke ShengDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, USA.
Daniel A LowDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, USA.
Leslie BallasDepartment of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Michael L SteinbergDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, USA.
Amar U KishanDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, USA.
Minsong CaoDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Magnetic Resonance Imaging (MRI)-guided Stereotactic body radiotherapy (SBRT) treatment to prostate bed after radical prostatectomy has garnered growing interests. The aim of this study is to evaluate intra-fractional anatomic and dose/volume metric variations for patients receiving this treatment. Materials and methods: Nineteen patients who received 30-34 Gy in 5 fractions on a 0.35T MR-Linac were included. Pre- and post-treatment MRIs were acquired for each fraction (total of 75 fractions). The Clinical Target Volume (CTV), bladder, rectum, and rectal wall were contoured on all images. Volumetric changes, Hausdorff distance, Mean Distance to Agreement (MDA), and Dice similarity coefficient (DSC) for each structure were calculated. Median value and Interquartile range (IQR) were recorded. Changes in target coverage and Organ at Risk (OAR) constraints were compared and evaluated using Wilcoxon rank sum tests at a significant level of 0.05. Results: Bladder had the largest volumetric changes, with a median volume increase of 48.9 % (IQR 28.9-76.8 %) and a median MDA of 5.1 mm (IQR 3.4-7.1 mm). Intra-fractional CTV volume remained stable with a median volume change of 1.2 % (0.0-4.8 %). DSC was 0.97 (IQR 0.94-0.99). For the dose/volume metrics, there were no statistically significant changes observed except for an increase in bladder hotspot and a decrease of bladder V Conclusion: Despite intra-fractional variations of OARs, CTV coverage remained stable during MRI-guided SBRT treatments for the prostate bed.

Indexed as

Intrafractional variationsMRgRTMRI guided radiotherapyPost-prostatectomyProstate cancer

Identifiers

PMID38585371
PMCPMC10997948

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