Evidence map›Paper›PMID 38585362›Full record

ArticleFrontiers in neurology2024

Altered tongue muscle contractile properties coincide with altered swallow function in the adult Ts65Dn mouse model of down syndrome.

Tiffany J Glass, John A Russell, Erin H Fisher, Marziyeh Ostadi, Nanyumuzi Aori, Y Eugene Yu, Nadine P Connor

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tiffany J GlassDepartment of Surgery, Division of Otolaryngology, University of Wisconsin-Madison, Madison, WI, United States.
John A RussellDepartment of Surgery, Division of Otolaryngology, University of Wisconsin-Madison, Madison, WI, United States.
Erin H FisherDepartment of Surgery, Division of Otolaryngology, University of Wisconsin-Madison, Madison, WI, United States.
Marziyeh OstadiDepartment of Surgery, Division of Otolaryngology, University of Wisconsin-Madison, Madison, WI, United States.
Nanyumuzi AoriDepartment of Surgery, Division of Otolaryngology, University of Wisconsin-Madison, Madison, WI, United States.
Y Eugene YuThe Children's Guild Foundation Down Syndrome Research Program, Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Nadine P ConnorDepartment of Surgery, Division of Otolaryngology, University of Wisconsin-Madison, Madison, WI, United States.
University of Wisconsin–Madison · USCancer Genetics (United States) · US

Funding

Mechanisms of Down syndrome-associated swallowing dysfunction in mouse modelsR01DC019735 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI NADINE P CONNOR, Tiffany Glass · 2022 to 2026
$3.4M
Mechanisms of swallowing dysfunction and rescue in a translational rat model of Alzheimer's diseaseR01AG085564 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI NADINE P CONNOR, Michelle Renee Ciucci · 2023 to 2026
$3.1M
Bioenergetic Mechanisms of Tongue Muscle FatigueR01DC018071 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI CONNOR, NADINE P · 2019 to 2023
$2.5M
NIA NIH HHS R01 AG085564NIDCD NIH HHS R01 DC018071NIDCD NIH HHS R01 DC019735
6 · The paper itself

Abstract

Purpose: Down syndrome (DS) is a developmental disability associated with difficulties in deglutition. The adult Ts65Dn mouse model of DS has been previously shown to have differences in measures of swallowing compared with euploid controls. However, the putative mechanisms of these differences in swallowing function are unclear. This study tested the hypothesis that the Ts65Dn genotype is associated with atypical measures of tongue muscle contractile properties, coinciding with atypical swallow function. Methods: Adult (5-month-old) Ts65Dn ( Results: The Ts65Dn group had significantly slower swallow rates, significantly greater ISI times, significantly slower rates of tongue force development, and significantly greater levels of tongue muscle fatigue, with lower retrusive tongue forces than controls in fatigue conditions. Conclusion: Tongue muscle contractile properties are altered in adult Ts65Dn and coincide with altered swallow function.

Indexed as

adultDown syndromemouseswallowtongueTs65Dn

Identifiers

PMID38585362
PMCPMC10995394
OpenAlexW4393091325

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.