Evidence map›Paper›PMID 38585272›Full record

ArticleFrontiers in immunology2024

Prevalence and duration of SARS-CoV-2 fecal shedding in breastfeeding dyads following maternal COVID-19 diagnosis.

Ryan M Pace, Elana A King-Nakaoka, Andrew G Morse, Kelsey J Pascoe, Anna Winquist, Beatrice Caffé, Alexandra D Navarrete, Kimberly A Lackey, Christina D W Pace, Bethaney D Fehrenkamp and 8 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ryan M PaceMargaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, ID, United States.
Elana A King-NakaokaUniversity of Washington School of Medicine, Seattle, WA, United States.
Andrew G MorseUniversity of Washington School of Medicine, Seattle, WA, United States.
Kelsey J PascoeCollege of Nursing, Washington State University, Spokane, WA, United States.
Anna WinquistCollege of Nursing, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Beatrice CafféDepartment of Anthropology, Washington State University, Pullman, WA, United States.
Alexandra D NavarreteDepartment of Medicine, Oregon Health and Sciences University, Portland, OR, United States.
Kimberly A LackeyMargaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, ID, United States.
Christina D W PaceMargaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, ID, United States.
Bethaney D FehrenkampMargaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, ID, United States.
Caroline B SmithDepartment of Anthropology, Washington State University, Pullman, WA, United States.
Melanie A MartinDepartment of Anthropology, University of Washington, Seattle, WA, United States.
Celestina Barbosa-LeikerCollege of Nursing, Washington State University, Spokane, WA, United States.
Sylvia H LeySchool of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, United States.
Mark A McGuireDepartment of Animal, Veterinary and Food Sciences, University of Idaho, Moscow, ID, United States.
Courtney L MeehanDepartment of Anthropology, Washington State University, Pullman, WA, United States.
Janet E WilliamsDepartment of Animal, Veterinary and Food Sciences, University of Idaho, Moscow, ID, United States.
Michelle K McGuireMargaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, ID, United States.

Funding

Scientific/Technical CoreP2CHD042828 · NICHD · UNIVERSITY OF WASHINGTON · PI SARA R. CURRAN · 2017 to 2026
$6.3M
Mammary and milk microbiomes and metabolomes - Understanding early variation and impacts on risk for mammary inflammation and mastitisR01HD092297 · NICHD · UNIVERSITY OF IDAHO · PI MCGUIRE, MICHELLE KAY · 2018 to 2022
$2.4M
Gates Foundation INV-016943NICHD NIH HHS P2C HD042828NICHD NIH HHS R01 HD092297
6 · The paper itself

Abstract

Background: There is a paucity of data on the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in feces of lactating women with coronavirus disease 2019 (COVID-19) and their breastfed infants as well as associations between fecal shedding and symptomatology. Objective: We examined whether and to what extent SARS-CoV-2 is detectable in the feces of lactating women and their breastfed infants following maternal COVID-19 diagnosis. Methods: This was a longitudinal study carried out from April 2020 to December 2021 involving 57 breastfeeding maternal-infant dyads: 33 dyads were enrolled within 7 d of maternal COVID-19 diagnosis, and 24 healthy dyads served as controls. Maternal/infant fecal samples were collected by participants, and surveys were administered via telephone over an 8-wk period. Feces were analyzed for SARS-CoV-2 RNA. Results: Signs/symptoms related to ears, eyes, nose, and throat (EENT); general fatigue/malaise; and cardiopulmonary signs/symptoms were commonly reported among mothers with COVID-19. In infants of mothers with COVID-19, EENT, immunologic, and cardiopulmonary signs/symptoms were most common, but prevalence did not differ from that of infants of control mothers. SARS-CoV-2 RNA was detected in feces of 7 (25%) women with COVID-19 and 10 (30%) of their infants. Duration of fecal shedding ranged from 1-4 wk for both mothers and infants. SARS-CoV-2 RNA was sparsely detected in feces of healthy dyads, with only one mother's and two infants' fecal samples testing positive. There was no relationship between frequencies of maternal and infant SARS-CoV-2 fecal shedding (

Indexed as

COVID-19Breast FeedingCOVID-19 TestingFecesFemaleHumansInfantLactationLongitudinal StudiesMalePrevalenceRNA, ViralSARS-CoV-2RNA, ViralbreastfeedingCOVID-19feceslactationmaternal-infant healthSARS-CoV-2symptomsviral shedding

Identifiers

PMID38585272
PMCPMC10996396

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.