Evidence map›Paper›PMID 38585186›Full record

ArticleOpen forum infectious diseases2024

Acute Hepatitis due to Primary Human Immunodeficiency Virus Infection.

Eric I Elliott, Daisy Smith, Jonathan Lipscomb, Bubu Banini, Lindsay Meurer, Thomas H Vanderford, Jeffrey A Johnson, Dhanpat Jain, Amit Achhra

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eric I ElliottSection of Infectious Disease, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0003-0630-3478
Daisy SmithThe DESA Group, Inc., Columbia, South Carolina, USA.
Jonathan LipscombHIV Laboratory Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Bubu BaniniSection of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0002-2972-9263
Lindsay MeurerDivision of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Thomas H VanderfordHIV Laboratory, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-5068-0900
Jeffrey A JohnsonHIV Laboratory, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Dhanpat JainDepartment of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0003-3845-0798
Amit AchhraSection of Infectious Disease, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
IMMUNOHEMATOLOGY/TRANSFUSION MEDICINE RESEARCH TRAININGT32HL007974 · NHLBI · YALE UNIVERSITY · PI JEANNE E HENDRICKSON, Diane S Krause · 2001 to 2026
$8.1M
TRAINING IN THE PATHOGENESIS OF INFECTIOUS DISEASEST32AI007517 · NIAID · YALE UNIVERSITY · PI Jaimie Meyer, Albert C Shaw · 1997 to 2026
$6.1M
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS T32 HL007974NIAID NIH HHS T32 AI007517
6 · The paper itself

Abstract

The acute retroviral syndrome may present with diverse systemic manifestations and laboratory abnormalities. Here we present a rare case of primary human immunodeficiency virus (HIV) infection causing severe acute hepatitis. Liver histopathology demonstrated a pattern of lymphocytic inflammation consistent with acute hepatitis, high levels of HIV proviral DNA were detected within liver tissue, and immunofluorescence showed HIV p24 antigen within immune and parenchymal cells including hepatocytes. We review the literature pertaining to HIV infection of cell compartments within the liver and discuss the implications for HIV-associated acute liver disease.

Indexed as

acute hepatitisacute HIV infectionacute retroviral syndromehistopathologyhuman immunodeficiency virusimmunofluorescenceimmunohistochemistryliverprimary HIV infectionproviral DNA

Identifiers

PMID38585186
PMCPMC10996125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.