Development of a Triphenylmethyl Alkylation Pre-Column Derivatization Method for HPLC Quantitative Analysis of Chemically Unstable Halogenated Compounds.

Jianwu Lu, Yinfei Shi, Xiaoxia Ye, Shun Yuan, Xiaolong Yang, Xun Sun, Taizhi Wu

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Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jianwu LuNational Key Laboratory of Lead Druggability Research (NKLLDR), Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai 201203, China.ORCID https://orcid.org/0000-0002-2998-8265

Yinfei ShiNational Key Laboratory of Lead Druggability Research (NKLLDR), Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai 201203, China.

Xiaoxia YeShanghai Institute for Food and Drug Control, National Medical Products Administration Key Laboratory for Quality Analysis of Chemical Drug Preparations, 1500 Zhangheng Road, Shanghai 201203, China.

Shun YuanNational Key Laboratory of Lead Druggability Research (NKLLDR), Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai 201203, China.

Xiaolong YangTechnical Economic Development Zone, Huanggang Luban Pharmaceutical Co., Ltd, Huanggang, Hubei 438011, China.

Xun SunDepartment of Natural Medicine, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.ORCID https://orcid.org/0000-0002-4316-2988

Taizhi WuNational Key Laboratory of Lead Druggability Research (NKLLDR), Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai 201203, China.ORCID https://orcid.org/0000-0002-6889-8801

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The primary limitations of the quantitative analysis of thermally labile halogenated compounds by traditional gas chromatography (GC) are the inadequacy of identifying the insufficiently volatile impurity (often with a high boiling point) and the difficulty in obtaining a standard substance with a reliable standardized assay. Taking the 4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one (DMDO-Cl,

Identifiers

PMID38585103

DOI10.1021/acsomega.3c09982

PMCPMC10993394

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.