Evidence map›Paper›PMID 38584932›Full record

ArticleFrontiers in public health2024

Epidemiology of enterotoxigenic

Monica J Pajuelo, Sassan Noazin, Lilia Cabrera, Angie Toledo, Mirza Velagic, Lucero Arias, Mayra Ochoa, Lawrence H Moulton, Mayuko Saito, Robert H Gilman and 1 more

Abstract read
In one paragraph

Article in Frontiers in public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Nutritional status and its association with early childhood caries in Peruvian pre-schoolers aged 3-5 years: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Article
  3. Review
  4. Streptococcus dentisani and Streptococcus mutans in dental biofilm of preschoolers with and without early childhood caries: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Building a Broader Understanding of EnterotoxigenicOpen forum infectious diseases · 2025
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Monica J PajueloLaboratorio Microbiología Molecular - Laboratorios de Investigación y Desarrollo, Facultad de Ciencias e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru.
Sassan NoazinDepartment of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
Lilia CabreraAsociación Benéfica Prisma, Lima, Peru.
Angie ToledoLaboratorio Microbiología Molecular - Laboratorios de Investigación y Desarrollo, Facultad de Ciencias e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru.
Mirza VelagicDepartment of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
Lucero AriasLaboratorio Microbiología Molecular - Laboratorios de Investigación y Desarrollo, Facultad de Ciencias e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru.
Mayra OchoaLaboratorio Microbiología Molecular - Laboratorios de Investigación y Desarrollo, Facultad de Ciencias e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru.
Lawrence H MoultonDepartment of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
Mayuko SaitoDepartment of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Robert H GilmanDepartment of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
Subhra ChakrabortyDepartment of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.

Funding

Natural infection of norovirus and sapovirus in a birth cohort in a Peruvian periurban communityR01AI108695 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CHAKRABORTY, SUBHRA, GILMAN, ROBERT H · 2015 to 2019
$5.0M
NIAID NIH HHS R01 AI108695
6 · The paper itself

Abstract

Background: Enterotoxigenic Methods: In a longitudinal birth cohort study of 345 children followed until 24 months of age in Lima, Peru, we measured ETEC burden in diarrheal and non-diarrheal samples using quantitative PCR (LT, STh, and STp toxin genes), studied epidemiology and measured anthropometry in children. Results: About 70% of children suffered from one or more ETEC diarrhea episodes. Overall, the ETEC incidence rate (IR) was 73 per 100 child-years. ETEC infections began early after birth causing 10% (8.9-11.1) ETEC-attributable diarrheal burden at the population level (PAF) in neonates and most of the infections (58%) were attributed to ST-ETEC [PAF 7.9% (1.9-13.5)] and LT + ST-ETEC (29%) of which all the episodes were associated with diarrhea. ETEC infections increased with age, peaking at 17% PAF (4.6-27.7%; Conclusion: This study showed that ETEC is a significant pathogen in Peruvian children who experience serial infections with multiple age-specific pathotypes, resulting in transitory growth impairment.

Indexed as

Enterotoxigenic Escherichia coliEscherichia coli InfectionsCohort StudiesDiarrheaEnterotoxinsHumansInfant, NewbornPeruEnterotoxinsbirth cohortcolonization factorsdiarrheadisease burdenenterotoxigenic E. coliepidemiologygrowth in childrenPeru

Identifiers

PMID38584932
PMCPMC10995271

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.