Evidence map›Paper›PMID 38584837›Full record

ArticleOpen medicine (Warsaw, Poland)2024

Identification and validation of autophagy-related genes in SSc.

Chen Liu, Xiaofang Guo, Maoyun Wei, Jiaxin Xie, Xuting Zhang, Qing Qi, Ke Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open medicine (Warsaw, Poland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chen LiuDepartment of Dermatology, Shenzhen People's Hospital, Shenzhen, Guangdong Province, China.
Xiaofang GuoThe First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.
Maoyun WeiDepartment of Dermatology, Second Hospital Affiliated to Guangzhou Medical University, Guangzhou 510260, China.
Jiaxin XieDepartment of Dermatology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.
Xuting ZhangThe First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.
Qing QiDepartment of Dermatology, Second Hospital Affiliated to Guangzhou Medical University, No. 250 Changgang Dong Road, Guangzhou 510260, China.
Ke ZhuDepartment of Dermatology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Airport Road No.16 Compound, Guangzhou, Guangdong Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple organs are affected by the complex autoimmune illness known as systemic sclerosis (SSc), which has a high fatality rate. Genes linked to autophagy have been linked to the aetiology of SSc. It is yet unknown, though, whether autophagy-related genes play a role in the aetiology of SSc. After using bioinformatics techniques to examine two databases (the GSE76885 and GSE95065 datasets) and autophagy-related genes, we were able to identify 12 autophagy-related differentially expressed genes that are linked to the pathophysiology of SSc. Additional examination of the receiver operating characteristic curve revealed that SFRP4 (AUC = 0.944,

Indexed as

autophagybioinformaticsimmune infiltrationsystemic sclerosis

Identifiers

PMID38584837
PMCPMC10998681

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.