ArticleToxicology reports2024
Water contamination: A culprit of serum heavy metals concentration, oxidative stress and health risk among residents of a Nigerian crude oil-producing community.
Article in Toxicology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Niger Delta has become popular for crude oil extraction for the past few decades. This uncoordinated activity has made it a hotspot for xenobiotics exposure and water bodies remain the environmental matrix significantly affected. One of the most deleterious components of crude oil is heavy metals (HMs). This study investigates HMs concentration in water and serum of humans residing in an oil-host community with the consideration of systemic effects, pollution status, carcinogenic and non-carcinogenic health risks and comparison made with residents from a non-oil-producing community. Heavy metal analysis, serum electrolytes, Urea, Creatinine, and liver enzymes were assessed using standard procedures; malondialdehyde, catalase, SOD, glutathione reductase, GPx and total antioxidant capacity (TAC) by spectrophotometry and TNF-α and 8-OHdG assessed via ELISA method. We found altered serum electrolytes; increased serum Pb and Cd levels; increased AST, ALT, ALP and lipid peroxidation; and decreased enzymes antioxidants including TAC among Ugbegugun community residents compared with control. We observed an association between environmental crude oil contamination, ecological and health risks in the community. We concluded that protracted exposure to HMs induces multi-systemic toxicities characterized by DNA damage, depletion of the antioxidant system, and increased free radical generation culminating lipo-peroxidation with significant ecological, carcinogenic, and non-carcinogenic risks characterize crude oil water contamination.
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