ArticleThe British journal of psychiatry : the journal of mental science2024
Towards precision in the diagnostic profiling of patients: leveraging symptom dynamics as a clinical characterisation dimension in the assessment of major depressive disorder.
Article in The British journal of psychiatry : the journal of mental science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- The effect of attentional bias modification on positive affect dynamics.Scientific reports · 2024Trial
- Rapid Innovation of Precision Psychiatry Interventions Using Dynamical Systems Modeling and Ecological Quasi-Experiments: Protocol for a Proof-of-Concept Study on Eating Disorders.JMIR research protocols · 2026Article
- Lower Severity, Denser Network: Profile-Specific Symptom Architecture in Adolescent Internalizing and Externalizing Problems.Behavioral sciences (Basel, Switzerland) · 2026Article
- Developmental dynamics of symptoms of emotional problems in childhood and adolescence: A longitudinal network analysis.JCPP advances · 2026Article
- Associations of cognitive impairment and physical disability with the risk and reversibility of depressive symptoms in Chinese older adults.BMC geriatrics · 2026Observational
- Distinguishing Chronic and Non-Chronic Depression: A Clinical Profile and Symptom Networks Approach.Psychotherapy and psychosomatics · 2026Article
- Symptom-specific links between internalizing problems and functional connectivity in adolescents: a network analysis.European child & adolescent psychiatry · 2026Article
- The diagnostic validity of central symptoms for major depressive disorder in adults with attention-deficit/hyperactivity disorder: a network analysis.European archives of psychiatry and clinical neuroscience · 2026Article
- Predicting Long-Term Depression Progression in Parkinson's Disease: A Machine-Learning Survival Analysis and Risk Score.CNS neuroscience & therapeutics · 2026Article
- Longitudinal associations between depressive symptoms and brain structure across late childhood and adolescence: A panel network analysis study.medRxiv : the preprint server for health sciences · 2026Article
- External factors show reproducible local symptom-biomarker associations in middle-aged and older adults with heart disease.Frontiers in psychiatry · 2026Article
- Exploring the interconnections between baseline symptoms in ultra-high risk youth who did and did not transition to psychosis over three years: A network analysis comparison.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Transdiagnostic Network Mapping of Psychopathology in Daily Life: Rationale and Research Protocol.Clinical psychology in Europe · 2025Article
- The effect of psychotherapy on the multivariate association between insomnia and depressive symptoms in late-life depression.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- The Potential of Personalized Post-Traumatic Stress Disorder Networks.Psychiatry and clinical psychopharmacology · 2025Article
- Longitudinal evolution of the transdiagnostic prodrome to severe mental disorders: a dynamic temporal network analysis informed by natural language processing and electronic health records.Molecular psychiatry · 2025Article
- Digital measures of activity and motivation impact depression and anxiety in the real world.NPJ digital medicine · 2025Article
- Symptom and Sentiment Analysis of Older People with Cancer and Caregivers: A Text Mining Approach Using Korean Social Media Data.Healthcare informatics research · 2025Article
- Transdiagnostic Compulsivity Traits in Problematic Use of the Internet Among UK Residents: Cross-Sectional Network Analysis Study.Journal of medical Internet research · 2025Article
- The effect of sertraline on networks of mood and anxiety symptoms: secondary analysis of the PANDA randomized controlled trial.Nature. Mental health · 2025Article
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7 authors.
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Abstract
backgroundInternational guidelines present overall symptom severity as the key dimension for clinical characterisation of major depressive disorder (MDD). However, differences may reside within severity levels related to how symptoms interact in an individual patient, called symptom dynamics.
aimsTo investigate these individual differences by estimating the proportion of patients that display differences in their symptom dynamics while sharing the same overall symptom severity.
methodParticipants with MDD (
resultsDifferential symptom dynamics were identified across 63.0% (95% bootstrapped CI 41.0-82.1) of participants within the same severity group. The average false detection of individual differences was 2.2%.
conclusionsThe majority of participants within the same depressive symptom severity group displayed differential symptom dynamics. Examining symptom dynamics provides information about person-specific psychopathological expression beyond severity levels by revealing how symptoms aggravate each other over time. These results suggest that symptom dynamics may be a promising new dimension for clinical characterisation, warranting replication in independent samples. To inform personalised treatment planning, a next step concerns linking different symptom relationship patterns to treatment response and clinical course, including patterns related to spontaneous recovery and forms of disorder progression.
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