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ArticleHypertension research : official journal of the Japanese Society of Hypertension2024

Blood pressure classification using the Japanese Society of Hypertension Guidelines for the Management of Hypertension and cardiovascular events among young to middle-aged working adults.

Keisuke Kuwahara, Takayoshi Ohkubo, Yosuke Inoue, Toru Honda, Shuichiro Yamamoto, Tohru Nakagawa, Hiroko Okazaki, Makoto Yamamoto, Toshiaki Miyamoto, Naoki Gommori and 7 more

Abstract read
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In one paragraph

Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Current hypertension epidemiology and contemporary approaches using the "Real-World Evidence Cycle" framework.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  5. Review
  6. Article
  7. The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025).Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  8. Understanding clinical inertia in hypertension management: clues from real-world data.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
  9. Article
  10. Article
  11. Long-term risk of cardiovascular mortality according to age group and blood pressure categories of the latest guideline.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
  12. Obstructive sleep apnea without obesity: the beginning of a journey to "NOOSA"?Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Keisuke KuwaharaDepartment of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan. kkuwahara@yokohama-cu.ac.jp.
Takayoshi OhkuboDepartment of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.
Yosuke InoueDepartment of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.
Toru HondaHitachi Healthcare Center, Hitachi, Ltd, Ibaraki, Japan.
Shuichiro YamamotoHitachi Healthcare Center, Hitachi, Ltd, Ibaraki, Japan.
Tohru NakagawaHitachi Healthcare Center, Hitachi, Ltd, Ibaraki, Japan.
Hiroko OkazakiMitsui Chemicals, Inc, Tokyo, Japan.
Makoto YamamotoYAMAHA CORPORATION, Shizuoka, Japan.
Toshiaki MiyamotoEAST NIPPON WORKS Kimitsu Area, NIPPON STEEL CORPORATION, Chiba, Japan.
Naoki GommoriEast Japan Works (Kehin), JFE Steel Corporation, Kanagawa, Japan.
Takeshi KochiFurukawa Electric Co., Ltd, Tokyo, Japan.
Takayuki OgasawaraMitsubishi Fuso Truck and Bus Corporation, Kanagawa, Japan.
Kenya YamamotoDivision of Chemical Information, National Institute of Occupational Safety and Health, Kawasaki, Kanagawa, Japan.
Maki KonishiDepartment of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.
Isamu KabeKUBOTA Corporation, Tokyo, Japan.
Seitaro DohiMitsui Chemicals, Inc, Tokyo, Japan.
Tetsuya MizoueDepartment of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Japanese Society of Hypertension updated guidelines for hypertension management (JSH2019), changing the blood pressure (BP) classification. However, evidence is sparse regarding the association of the classification with cardiovascular disease (CVD) events among young to middle-aged workers in Japan. We examined this issue using longitudinal data from Japan Epidemiology Collaboration on Occupational Health Study with a prospective cohort design. Participants were 81,876 workers (aged 20-64 years) without taking antihypertensive medication at baseline. BP in 2011 or 2010 was used as exposure. CVD events that occurred from 2012 to 2021 were retrieved from a within-study registry. Cox regression was used to calculate multivariable-adjusted hazard ratios of CVD events. During 0.5 million person-years of follow-up, 334 cardiovascular events, 75 cardiovascular deaths, and 322 all-cause deaths were documented. Compared with normal BP (systolic BP [SBP] < 120 mmHg and diastolic BP [DBP] < 80 mmHg), multivariable-adjusted hazard ratios (95% confidence intervals) of cardiovascular events were 1.98 (1.49-2.65), 2.10 (1.58-2.77), 3.48 (2.33-5.19), 4.12 (2.22-7.64), and 7.81 (3.99-15.30) for high normal BP (SBP120-129 mmHg and DBP < 80 mmHg), elevated BP (SBP130-139 mmHg and/or DBP80-89 mmHg), stage 1 hypertension (SBP140-159 mmHg and DBP90-99 mmHg), stage 2 hypertension (SBP160-179 mmHg and/or DBP100-109 mmHg), and stage 3 hypertension (SBP ≥ 180 mmHg and/or DBP ≥ 110 mmHg), respectively. The highest population attributable fraction was observed in elevated BP (17.8%), followed by stage 1 hypertension (14.1%). The present data suggest that JSH2019 may help identify Japanese workers at a higher cardiovascular risk.

Indexed as

Blood PressureCardiovascular DiseasesHypertensionAdultEast Asian PeopleFemaleHumansJapanLongitudinal StudiesMaleMiddle AgedPractice Guidelines as TopicProspective StudiesYoung AdultBlood pressureCardiovascular eventsCohort studyJapanWorking population

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.