Evidence map›Paper›PMID 38583987›Full record

ArticleAnnals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia2024

Prognostic Impact of Serum SCC Antigen in the 566 Upfront Surgery Group of Esophageal Squamous Cell Carcinoma: A Multi-Institutional Study of the Japan Esophageal Society.

Takashi Suzuki, Satoshi Yajima, Akihiko Okamura, Naoya Yoshida, Yusuke Taniyama, Kentaro Murakami, Yu Ohkura, Yasuaki Nakajima, Koichi Yagi, Takashi Fukuda and 7 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 15 institutions in 1 country.

Takashi SuzukiDepartment of Gastroenterological Surgery and Clinical Oncology, Graduate School of Medicine, Toho University, Tokyo, Japan.
Satoshi YajimaDepartment of Gastroenterological Surgery and Clinical Oncology, Graduate School of Medicine, Toho University, Tokyo, Japan.
Akihiko OkamuraDepartment of Gastroenterological Surgery, Gastroenterology Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
Naoya YoshidaDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Kumamoto, Japan.
Yusuke TaniyamaDepartment of Digestive Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Kentaro MurakamiDepartment of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan.
Yu OhkuraDepartment of Gastroenterological Surgery, Toranomon Hospital, and Okinaka Memorial Institute for Medical Research, Tokyo, Japan.
Yasuaki NakajimaDepartment of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Koichi YagiDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Takashi FukudaDepartment of Gastroenterological Surgery, Saitama Cancer Center Hospital, Kitaadachi-gun, Saitama, Japan.
Ryo OgawaDepartment of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.
Isamu HoshinoDivision of Gastroenterological Surgery, Chiba Cancer Center, Chiba, Chiba, Japan.
Chikara KunisakiDepartment of Surgery, Gastroenterological Center, Yokohama City University, Yokohama, Kanagawa, Japan.
Kosuke NarumiyaDepartment of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Yasuhiro TsubosaDivision of Esophageal Surgery, Shizuoka Cancer Center, Sunto-gun, Shizuoka, Japan.
Kazuhiko YamadaDepartment of Surgery, National Center for Global Health and Medicine, Tokyo, Japan.
Hideaki ShimadaDepartment of Gastroenterological Surgery and Clinical Oncology, Graduate School of Medicine, Toho University, Tokyo, Japan.ORCID http://orcid.org/0000-0002-1990-8217
Toho University · JPChiba Cancer Center · JPChiba University · JPKumamoto University · JPNagoya City University · JPNational Center for Global Health and Medicine · JPSaitama Cancer Center · JPShizuoka Cancer Center · JPThe Cancer Institute Hospital · JPThe University of Tokyo · JPTohoku University · JPTokyo Medical and Dental University · JPTokyo Women's Medical University · JPToranomon Hospital · JPYokohama City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to determine the clinicopathologic and prognostic significance of squamous cell carcinoma antigen (SCC-Ag) in patients with esophageal SCC who underwent radical surgery without neoadjuvant therapy.

methodsThis study included 566 patients with primary esophageal SCC who underwent radical resection without neoadjuvant therapy at 15 Japanese hospitals between 2008 and 2016. The cutoff value of SCC-Ag was 1.5 ng/mL based on the receiver operating characteristic curves. Preoperative SCC-Ag and postoperative SCC-Ag were analyzed to evaluate clinicopathological and prognostic significance. Survival curves were compared between the SCC-Ag-positive group and the SCC-Ag-negative group. The prognostic impact of SCC-Ag was evaluated using univariate and multivariate analyses.

resultsThe preoperative SCC-Ag-positive rate was 23.5% (133/566). SCC-Ag-positive status was significantly associated with old age (p = 0.042), tumor depth (p <0.001), and tumor stages (p <0.001). The preoperative SCC-Ag-positive group had significantly poorer overall survival than the SCC-Ag-negative group (p = 0.030), but it was not an independent predictor of poor prognosis. Postoperative SCC-Ag-positive status was an independent risk factor for poor overall survival (p = 0.034).

conclusionBoth pre- and postoperative SCC-Ag-positive statuses were significantly associated with poor prognosis. Postoperative SCC-Ag-positive status was an independent risk factor for predicting overall survival.

Indexed as

Antigens, NeoplasmCarcinoma, Squamous CellEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaSerpinsBiomarkers, TumorHumansJapanNeoplasm StagingPrognosisRetrospective StudiesTreatment OutcomeAntigens, NeoplasmBiomarkers, TumorSerpinssquamous cell carcinoma-related antigenesophageal squamous cell carcinomaprognosissquamous cell carcinoma antigen

Identifiers

PMID38583987
PMCPMC11082496
OpenAlexW4393955283

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.