ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2024
Sociodemographic and clinical characteristics associated with maternal and congenital syphilis - A prospective study in Peru.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 2 citations in OpenAlex.
- Congenital Syphilis Elimination in Latin America: A Systematic Analysis of Policy and Progress.Sexually transmitted diseases · 2026Article
- Strengthening STD Screening Programs: Comprehensive Evaluation of High-Throughput Immunoassays for HIV and Syphilis Detection.Microorganisms · 2026Article
- Assessing progress towards the elimination of mother-to-child transmission of syphilis in Peru: A national retrospective analysis.PLOS global public health · 2026Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesThe objective of this study was to explore the factors and outcomes associated with gestational syphilis in Peru.
methodsWomen from the miscarriage, vaginal delivery, and C-section wards from a large maternity hospital in Lima with or without syphilis diagnosis were enrolled and their pregnancy outcomes compared. Maternal syphilis status using maternal blood and child serostatus using cord blood were determined by rapid plasma reagin (RPR) and rapid syphilis tests. The newborns' clinical records were used to determine congenital syphilis.
resultsA total of 340 women were enrolled, 197 were positive and 143 were negative for RPR/rapid syphilis tests. Antibody titers in sera from cord and maternal blood were comparable with RPR titers and were highly correlated (rho = 0.82, P <0.001). Young age (P = 0.009) and lower birth weight (P = 0.029) were associated with gestational syphilis. Of the women with gestational syphilis, 76% had received proper treatment. Mothers of all newborns with congenital syphilis also received appropriate treatment. Treatment of their sexual partners was not documented.
conclusionsSyphilis during pregnancy remains a major cause of the fetal loss and devastating effects of congenital syphilis in newborns.
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