Evidence map›Paper›PMID 38583723›Full record

ArticleGastroenterology2024

Impaired Glycosylation of Gastric Mucins Drives Gastric Tumorigenesis and Serves as a Novel Therapeutic Target.

Junya Arai, Yoku Hayakawa, Hiroaki Tateno, Keita Murakami, Takeru Hayashi, Masahiro Hata, Yuki Matsushita, Hiroto Kinoshita, Sohei Abe, Ken Kurokawa and 26 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Article
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  4. Article
  5. Article
  6. Review
  7. Review
  8. Managing dangerous liaisons: lessons fromJournal of bacteriology · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Golgi Drivers of Cancer.Sub-cellular biochemistry · 2026
    Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Multiple roles and mechanisms of MUC6 in cancer (Review).International journal of molecular medicine · 2025
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Junya AraiDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan; Division of Gastroenterology, The Institute of Medical Science, Asahi Life Foundation, Tokyo, Japan.
Yoku HayakawaDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. Electronic address: yhayakawa-tky@umin.ac.jp.
Hiroaki TatenoCellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan. Electronic address: h-tateno@aist.go.jp.
Keita MurakamiDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Takeru HayashiDivision of Microbiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan; Laboratory of Microbial Carcinogenesis, Institute of Microbial Chemistry, Microbial Chemistry Research Foundation, Tokyo, Japan.
Masahiro HataDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Yuki MatsushitaDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Hiroto KinoshitaDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Sohei AbeDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Ken KurokawaDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Yukiko OyaDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Mayo TsuboiDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Sozaburo IharaDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Ryota NiikuraDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Nobumi SuzukiDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Yusuke IwataDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Toshiro ShiokawaDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Chihiro ShiomiDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Chie UekuraDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Keisuke YamamotoDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Hiroaki FujiwaraDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan; Division of Gastroenterology, The Institute of Medical Science, Asahi Life Foundation, Tokyo, Japan.
Satoshi KawamuraDepartment of Gastroenterology, Graduate School of Medicine, Mie University, Mie, Japan.
Hayato NakagawaDepartment of Gastroenterology, Graduate School of Medicine, Mie University, Mie, Japan.
Seiya MizunoLaboratory Animal Resource Center in Transborder Medical Research Center, and Department of Laboratory Animal Science, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Takashi KudoLaboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Satoru TakahashiLaboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Tetsuo UshikuDepartment of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Yoshihiro HirataDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Chifumi FujiiDepartment of Molecular Pathology, Shinshu University School of Medicine, Matsumoto, Japan; Department of Biotechnology, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, Matsumoto, Japan.
Jun NakayamaDepartment of Molecular Pathology, Shinshu University School of Medicine, Matsumoto, Japan.
Shinsuke ShibataDivision of Microscopic Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Susan WoodsPrecision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia; Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
Daniel L WorthleyColonoscopy Clinic, Brisbane, Queensland, Australia.
Masanori HatakeyamaDivision of Microbiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan; Laboratory of Microbial Carcinogenesis, Institute of Microbial Chemistry, Microbial Chemistry Research Foundation, Tokyo, Japan; Center of Infection-Associated Cancer, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.
Timothy C WangDivision of Digestive and Liver Disease, Department of Medicine, Columbia University, New York, New York.
Mitsuhiro FujishiroDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

Funding

The Role of Stem Cells and the Microenvironment in Gastrointestinal CancersR35CA210088 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Timothy Cragin Wang · 2017 to 2026
$10.2M
THE FUNCTION AND REGULATION OF HISTIDINE DECARBOXYLASE IN GUT INFLAMMATIONR01DK048077 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WANG, TIMOTHY CRAGIN · 1995 to 2020
$5.9M
Gastroesophageal junction stem cells as the origin of Barretts esophagus and cancerR01CA272901 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN, WANG, TIMOTHY CRAGIN · 2022 to 2025
$4.9M
NCI NIH HHS R01 CA272901NCI NIH HHS R35 CA210088NIDDK NIH HHS R01 DK048077
6 · The paper itself

Abstract

BACKGROUND &

aimsGastric cancer is often accompanied by a loss of mucin 6 (MUC6), but its pathogenic role in gastric carcinogenesis remains unclear.

methodsMuc6 knockout (Muc6

resultsDeletion of Muc6 in mice spontaneously causes pan-gastritis and invasive gastric cancers. Muc6-deficient tumor growth was dependent on mitogen-activated protein kinase activation, mediated by Golgi stress-induced up-regulation of Golgi phosphoprotein 3. Glycomic profiling revealed aberrant expression of mannose-rich N-linked glycans in gastric tumors, detected with banana lectin in association with lack of MUC6 expression. We identified a precursor of clusterin as a binding partner of mannose glycans. Mitogen-activated protein kinase activation, Golgi stress responses, and aberrant mannose expression are found in separate Cosmc- and A4gnt-deficient mouse models that lack normal O-glycosylation. Banana lectin-drug conjugates proved an effective treatment for mannose-rich murine and human gastric cancer.

conclusionsWe propose that Golgi stress responses and aberrant glycans are important drivers of and promising new therapeutic targets for gastric cancer.

Indexed as

Mice, KnockoutMucin-6Stomach NeoplasmsAnimalsCarcinogenesisCell Line, TumorDisease Models, AnimalGastric MucinsGastric MucosaGlycosylationGolgi ApparatusHumansMiceOrganoidsTrefoil Factor-1Gastric MucinsMucin-6Tff1 protein, mouseTrefoil Factor-1Gastric CancerGolgi StressGOLPH3MAPK PathwayMuc6

Identifiers

PMID38583723
PMCPMC12197564

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.