Evidence map›Paper›PMID 38583465›Full record

ArticleReproduction & fertility2024

The (cost-) effectiveness Of Surgical excision of Colorectal endometriosis compared to ART treatment trAjectory (TOSCA study) - a study protocol.

Rozemarijn de Koning, Astrid E P Cantineau, Karin van der Tuuk, Bianca De Bie, Henk Groen, M Elske van den Akker-van Marle, Annemiek W Nap, Jacques W M Maas, Frank Willem Jansen, Andries R H Twijnstra and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproduction & fertility, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rozemarijn de KoningR de Koning, Leiden University Medical Center, Leiden, Netherlands.
Astrid E P CantineauA Cantineau, Obstetrics and Gynaecology, University Medical Centre Groningen, Groningen, Netherlands.
Karin van der TuukK van der Tuuk, Department of Obstetrics and Gynaecology, University Medical Centre Groningen, Groningen, Netherlands.
Bianca De BieB De Bie, Endometriosis Foundation of the Netherlands, Sittard, Netherlands.
Henk GroenH Groen, Epidemiology, University Medical Centre Groningen, Groningen, Netherlands.
M Elske van den Akker-van MarleM van den Akker-van Marle, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, Netherlands.
Annemiek W NapA Nap, Department of Obstetrics and Gynaecology, Radboudumc, Nijmegen, Netherlands.
Jacques W M MaasJ Maas, Department of Gynaecology and Grow-school of Oncology and Reproduction, Maastricht University Medical Centre+, Maastricht, Netherlands.
Frank Willem JansenF Jansen, Department of Gynaecology, Leiden University Medical Centre, Leiden, Netherlands.
Andries R H TwijnstraA Twijnstra, Department of Gynaecology, Leiden University Medical Centre, Leiden, Netherlands.
Mathijs D BlikkendaalM Blikkendaal, Department of Gynaecology, Leiden University Medical Center, Leiden, 2300 RC, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, the optimal treatment to increase the chance of pregnancy and live birth in patients with colorectal endometriosis and subfertility is unknown. Evidence suggests that that both surgery and in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) are effective in improving live birth rate (LBR) among these women. However, the available evidence is of low quality, reports highly heterogeneous results, lacks direct comparison between both treatment options and does not assess whether a combination strategy results in a higher LBR compared to IVF/ICSI-only treatment. Additionally, the optimal timing of surgery within the treatment trajectory remains unclear. The primary objective of the TOSCA study is to assess the effectiveness of surgical treatment (potentially combined with IVF/ICSI) compared to IVF/ICSI-only treatment to increase the chance of an ongoing pregnancy resulting in a live birth in patients with colorectal endometriosis and subfertility, measured by cumulative LBR. Secondary objectives are to assess and compare quality of life and cost-effectiveness in both groups. Patients will be followed for 40 months after inclusion or until live birth. The TOSCA study is expected to be completed in 6 years.

Identifiers

PMID38583465
PMCPMC11103752

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.