ArticleDevelopmental cognitive neuroscience2024
A general exposome factor explains individual differences in functional brain network topography and cognition in youth.
Article in Developmental cognitive neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- The ABCD Study at 10: The NIH perspective on progress, impact, and the road ahead.Developmental cognitive neuroscience · 2026Article
- Multivariate environmental exposures are reflected in whole-brain functional connectivity and cognition in youth.Developmental cognitive neuroscience · 2026Article
- Neuroanatomical Subtypes of Callous-Unemotional Traits in a Community Sample of Youth.bioRxiv : the preprint server for biology · 2026Article
- Linking the exposome to the brain-behaviour phenotype.Nature reviews. Neuroscience · 2026Review
- Challenges and opportunities of gap score methods for studying psychopathology resilience and vulnerability.medRxiv : the preprint server for health sciences · 2026Article
- Neighborhood air pollution is associated with attenuated neurocognitive maturation over early adolescence.Developmental cognitive neuroscience · 2026Article
- Task and Resting-State Functional Magnetic Resonance Imaging Modeling of Brain-Behavior Relationships in Developmental Cohorts.Biological psychiatry · 2026Review
- White matter reflects the childhood exposome.bioRxiv : the preprint server for biology · 2026Article
- Menarche onset is an inflection point for mental health and brain development.bioRxiv : the preprint server for biology · 2026Article
- Household Adversity, Day to Day Experiences, and Birth/Pregnancy Complications are Associated with Delay Discounting: Findings from the Adolescent Brain Cognitive Development Study.Research on child and adolescent psychopathology · 2026Article
- The effect of the "exposome" on developmental brain health and cognitive outcomes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Lifestyle and Transcriptional Signatures Associated with Ethnicity/Race-Related Variations in the Functional Connectome.Research (Washington, D.C.) · 2026Article
- Investigating hierarchical critical periods in human neurodevelopment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Cognition varies across the calendar year in multiple large-scale datasets.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Multivariate environmental exposures are reflected in whole-brain functional connectivity and cognition in youth.bioRxiv : the preprint server for biology · 2025Article
- Mapping the development of neural structures supporting literacy.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Precision functional mapping reveals less inter-individual variability in the child vs. adult human brain.bioRxiv : the preprint server for biology · 2025Article
- Exploration is associated with socioeconomic disparities in learning and academic achievement in adolescence.Nature communications · 2025Article
- Reproducible sex differences in personalised functional network topography in youth.The British journal of psychiatry : the journal of mental science · 2025Article
- Mapping individualized multi-scale hierarchical brain functional networks from fMRI by self-supervised deep learning.bioRxiv : the preprint server for biology · 2025Article
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19 authors.
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Abstract
Childhood environments are critical in shaping cognitive neurodevelopment. With the increasing availability of large-scale neuroimaging datasets with deep phenotyping of childhood environments, we can now build upon prior studies that have considered relationships between one or a handful of environmental and neuroimaging features at a time. Here, we characterize the combined effects of hundreds of inter-connected and co-occurring features of a child's environment ("exposome") and investigate associations with each child's unique, multidimensional pattern of functional brain network organization ("functional topography") and cognition. We apply data-driven computational models to measure the exposome and define personalized functional brain networks in pre-registered analyses. Across matched discovery (n=5139, 48.5% female) and replication (n=5137, 47.1% female) samples from the Adolescent Brain Cognitive Development study, the exposome was associated with current (ages 9-10) and future (ages 11-12) cognition. Changes in the exposome were also associated with changes in cognition after accounting for baseline scores. Cross-validated ridge regressions revealed that the exposome is reflected in functional topography and can predict performance across cognitive domains. Importantly, a single measure capturing a child's exposome could more accurately and parsimoniously predict cognition than a wealth of personalized neuroimaging data, highlighting the importance of children's complex, multidimensional environments in cognitive neurodevelopment.
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