ArticleMolecular therapy : the journal of the American Society of Gene Therapy2024
A p21-ATD mouse model for monitoring and eliminating senescent cells and its application in liver regeneration post injury.
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Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11citing papers in PubMed
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Genomic, epigenomic and transcriptomic regulation of cellular senescence.Nature reviews. Genetics · 2026Review
- A multimodal ROS logic-gated therapeutic platform disrupts the vicious cycle of senescence to promote aged bone defect repair.Bioactive materials · 2026Article
- Review
- Comprehensive characterisation of age-related changes in cell subpopulations and tissue structural properties in secondary lymphoid organs.Cell death & disease · 2025Article
- The context-dependent effect of cellular senescence: From embryogenesis and wound healing to aging.Ageing research reviews · 2025Review
- Stem cell-based therapeutic strategies for liver aging.Liver research (Beijing, China) · 2025Review
- Targeting p21-Positive Senescent Chondrocytes via IL-6R/JAK2 Inhibition to Alleviate Osteoarthritis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics.Signal transduction and targeted therapy · 2025Review
- Therapeutic potential of nicotinamide and ABT263 in alcohol-associated liver disease through targeting cellular senescence.MedComm · 2025Article
- GATD3A-deficiency-induced mitochondrial dysfunction facilitates senescence of fibroblast-like synoviocytes and osteoarthritis progression.Nature communications · 2024Article
- Cellular senescence in metastatic prostate cancer: A therapeutic opportunity or challenge (Review).Molecular medicine reports · 2024Review
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Authors and funding
19 authors at 2 institutions in 1 country.
Miaomiao ChenInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200123, P.R. China; Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai 200335, P.R. China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200123, P.R. China.
Guoxiu WuInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200123, P.R. China; Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai 200335, P.R. China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200123, P.R. China.
Yanli LuInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200123, P.R. China; Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai 200335, P.R. China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200123, P.R. China.
Shiwen SunInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200123, P.R. China; Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai 200335, P.R. China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200123, P.R. China.
Zhao YuInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200123, P.R. China; Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai 200335, P.R. China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200123, P.R. China.
Xin PanInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200123, P.R. China; Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai 200335, P.R. China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200123, P.R. China.
Wenjian ChenInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200123, P.R. China; Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai 200335, P.R. China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200123, P.R. China.
Hongyu XuInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200123, P.R. China; Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai 200335, P.R. China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200123, P.R. China.
Hua QiuDepartment of General Surgery, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province 330006, P.R. China.
Weizhi HeInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200123, P.R. China; Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai 200335, P.R. China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200123, P.R. China.
Xiuhua LiInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200123, P.R. China; Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai 200335, P.R. China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200123, P.R. China.
Xicheng WangInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200123, P.R. China; Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai 200335, P.R. China; Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China.
Yi LuoInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200123, P.R. China; Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai 200335, P.R. China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200123, P.R. China.
Yuan DuDepartment of General Surgery, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province 330006, P.R. China.
Jialing WuInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200123, P.R. China; Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai 200335, P.R. China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200123, P.R. China.
Ke WeiInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200123, P.R. China.
Wencheng ZhangInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200123, P.R. China; Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai 200335, P.R. China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200123, P.R. China.
Zhongmin LiuInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200123, P.R. China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200123, P.R. China; Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China.
Zhiying HeInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200123, P.R. China; Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai 200335, P.R. China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200123, P.R. China. Electronic address: zyhe@tongji.edu.cn.
Shanghai East Hospital · CNNanchang University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular senescence associates with pathological aging and tissue dysfunctions. Studies utilizing mouse models for cell lineage tracings have emphasized the importance of senescence heterogeneity in different organs and cell types. Here, we constructed a p21- (Akaluc - tdTomato - Diphtheria Toxin Receptor [DTR]) (ATD) mouse model to specifically study the undefined mechanism for p21-expressing senescent cells in the aged and liver injury animals. The successful expressions of these genes enabled in vitro flow cytometric sorting, in vivo tracing, and elimination of p21-expressing senescent cells. During the natural aging process, p21-expressing cells were found in various tissues of p21-ATD mice. Eliminating p21-expressing cells in the aged p21-ATD mice recovered their multiple biological functions. p21-ATD/Fah
Indexed as
Cellular SenescenceCyclin-Dependent Kinase Inhibitor p21Disease Models, AnimalHepatocytesLiver RegenerationAnimalsHydrolasesLiverMiceMice, KnockoutMice, TransgenicCyclin-Dependent Kinase Inhibitor p21fumarylacetoacetaseHydrolasesagingcellular senescenceliver regenerationp21senescent cell elimination
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