ArticlePediatric research2024
Impact of different growth hormone levels on gut microbiota and metabolism in short stature.
Article in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- The impact of growth hormone therapy on ocular structural parameters in idiopathic short stature: a systematic review and meta-analysis.European journal of pediatrics · 2026Pooled it
- Gut microbiota profiles in Korean children with growth hormone deficiency: a case-control study.Clinical and experimental pediatrics · 2026Article
- Oral and gut microbiota after acromegaly treatment: prospective assessment and insights from machine learning.Pituitary · 2025Article
- Children with idiopathic short stature and growth hormone deficiency exhibit similar changes in gut microbiota.Endocrine journal · 2025Article
- Dysbiosis of gut microbiota with enriched pro-inflammatory species in children with idiopathic short stature: a case-control study.Scientific reports · 2025Article
- Research progress in abnormal carbohydrate, lipid, and protein metabolism in children with isolated growth hormone deficiency.Frontiers in endocrinology · 2025Review
- Gut-brain-liver axis in growth hormone deficiency: role of microbiota-derived short-chain fatty acids in ethnic variability and therapeutic development.Frontiers in public health · 2025Review
- The critical role of diet, exercise, and sleep in shaping the gut microbiota of children with idiopathic short stature: a Retrospective study.Frontiers in immunology · 2025Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundGrowth hormone deficiency(GHD) and idiopathic short stature(ISS) are the primary causes of short stature in children. Animal experiments have revealed a link between growth hormone(GH), gut microbiota and metabolism, however, limited information is available from human trials.
methodsFecal samples collected from GHD (n = 36), ISS (n = 32) and healthy control (HC) children(n = 16) were subjected to microbiome (16 S rRNA gene sequencing) and metabolome (nuclear magnetic resonance,NMR) analyses.
resultsGHD, ISS and HC exhibit distinct differences in beta diversity of gut microbiota.In addition, short stature (GHD and ISS) exhibit higher relative abundance of Prevotellaceae_NK3B31_group at genus level compared to HC, whereas Rodentibacter, Rothia, and Pelomonas showed lower abundance. Additionally,Fusobacterium_mortiferum was identified as the characteristic species of GHD. Moreover, glucose metabolism, pyruvate metabolism and pyrimidine metabolism might play significant roles for distinguishing between GHD and normal GH groups (ISS and HC). Furthermore, a disease prediction model based on differential bacteria and metabolites between GHD and ISS exhibited high diagnostic value.
conclusionThese findings highlight the characteristics of different GH levels on the gut microbiota and metabolism in children, providing novel perspectives for early diagnosis and prognostic treatment of short stature with abnormal GH levels. IMPACT: The key message of our study is to identify human-relevant gut microbiota and host metabolic patterns that are interfered with growth hormone levels, and to develop biomarker models to identify short stature associated with growth hormone deficiency. We used idiopathic short stature as a control group for growth hormone deficiency, complementing the absence of height as a factor in the existing literature. Our study ultimately hopes to shed new light on the diagnosis and treatment of short stature children associated with growth hormone deficiency.
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Registered trials
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