Evidence map›Paper›PMID 38582332›Full record

ArticleNeurotoxicology2024

Olfactory tract/bulb metal concentration in Manganese-exposed mineworkers.

Luis F Gonzalez-Cuyar, Gill Nelson, Susan Searles Nielsen, Wendy W Dlamini, Amelia Keyser-Gibson, C Dirk Keene, Michael Paulsen, Susan R Criswell, Natalie Senini, Lianne Sheppard and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotoxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Manganese-Induced Parkinsonism: A Review of Etiologies and Treatments.Degenerative neurological and neuromuscular disease · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Luis F Gonzalez-CuyarUniversity of Washington, School of Medicine and Department of Laboratory Medicine and Pathology, Division of Neuropathology, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: luisgonz@uw.edu.
Gill NelsonSchool of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St Andrews Rd, Parktown 2193, South Africa; Department of Neurology, Barrow Neurological Institute, 240 W Thomas Rd, Phoenix, AZ 85013, USA.
Susan Searles NielsenDepartment of Neurology, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO 63110, USA.
Wendy W DlaminiDepartment of Neurology, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO 63110, USA; Department of Epidemiology, School of Public Health, University of Washington, 3980 15th Ave NE, Seattle, WA 98195, USA.
Amelia Keyser-GibsonUniversity of Washington, School of Medicine and Department of Laboratory Medicine and Pathology, Division of Neuropathology, 325 9th Ave, Seattle, WA 98104, USA.
C Dirk KeeneUniversity of Washington, School of Medicine and Department of Laboratory Medicine and Pathology, Division of Neuropathology, 325 9th Ave, Seattle, WA 98104, USA.
Michael PaulsenDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA.
Susan R CriswellDepartment of Neurology, Barrow Neurological Institute, 240 W Thomas Rd, Phoenix, AZ 85013, USA; Department of Neurology, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO 63110, USA.
Natalie SeniniDepartment of Neurology, Barrow Neurological Institute, 240 W Thomas Rd, Phoenix, AZ 85013, USA.
Lianne SheppardDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA; Department of Biostatistics, School of Public Health, University of Washington, 3980 15th Ave NE, Seattle, WA 98195, USA.
Shar SamyDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA.
Christopher D SimpsonDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA.
Marissa G BakerDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA.
Brad A RacetteSchool of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St Andrews Rd, Parktown 2193, South Africa; Department of Neurology, Barrow Neurological Institute, 240 W Thomas Rd, Phoenix, AZ 85013, USA; Department of Neurology, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO 63110, USA.
University of Washington · USBarrow Neurological Institute · USWashington University in St. Louis · US

Funding

University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI SUMAN JAYADEV · 2020 to 2026
$29.0M
Manganese-Induced Neurotoxic Effects Research in South Africa (MINERS)R01ES026891 · NIEHS · WASHINGTON UNIVERSITY · PI RACETTE, BRAD A · 2017 to 2021
$3.3M
NIA NIH HHS P30 AG066509NIEHS NIH HHS R01 ES026891
6 · The paper itself

Abstract

backgroundManganese (Mn) is an essential micronutrient as well as a well-established neurotoxicant. Occupational and environmental exposures may bypass homeostatic regulation and lead to increased systemic Mn levels. Translocation of ultrafine ambient airborne particles via nasal neuronal pathway to olfactory bulb and tract may be an important pathway by which Mn enters the central nervous system.

objectiveTo measure olfactory tract/bulb tissue metal concentrations in Mn-exposed and non-exposed mineworkers.

methodsUsing inductively coupled plasma-mass spectrometry (ICP-MS), we measured and compared tissue metal concentrations in unilateral olfactory tracts/bulbs of 24 Mn-exposed and 17 non-exposed South African mineworkers. We used linear regression to investigate the association between cumulative Mn exposures and olfactory tract/bulb Mn concentration.

resultsThe difference in mean olfactory tract/bulb Mn concentrations between Mn-exposed and non-Mn exposed mineworkers was 0.16 µg/g (95% CI -0.11, 0.42); but decreased to 0.09 µg/g (95% CI 0.004, 0.18) after exclusion of one influential observation. Olfactory tract/bulb metal concentration and cumulative Mn exposure suggested there may be a positive association; for each mg Mn/m

conclusionsOur findings suggest that Mn-exposed mineworkers might have higher olfactory tract/bulb tissue Mn concentrations than non-Mn exposed mineworkers, and that concentrations might depend more on cumulative dose than recency of exposure.

Indexed as

ManganeseOccupational ExposureOlfactory BulbAdultFemaleHumansMaleMiddle AgedMiningOlfactory PathwaysSouth AfricaYoung AdultManganeseICP-MSManganeseMetals exposureMineworkersMRIOlfactorySouth Africa

Identifiers

PMID38582332
PMCPMC12108453
OpenAlexW4394761236

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.