Evidence map›Paper›PMID 38582071›Full record

ArticleClinical imaging2024

Assessing breast arterial calcification in mammograms and its implications for atherosclerotic cardiovascular disease risk.

Shadi Azam, Rulla M Tamimi, Michele B Drotman, Kemi Babagbemi, Allison D Levy, Jessica M Peña

Open access · greenAbstract read
In one paragraph

Article in Clinical imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Shadi AzamDepartment of Population Health Sciences, Weill Cornell Medicine, New York, USA. Electronic address: sha4015@med.cornell.edu.
Rulla M TamimiDepartment of Population Health Sciences, Weill Cornell Medicine, New York, USA. Electronic address: rmt4001@med.cornell.edu.
Michele B DrotmanDepartment of Diagnostic Radiology, Weill Cornell Medicine, New York, USA. Electronic address: mid2011@med.cornell.edu.
Kemi BabagbemiDepartment of Diagnostic Radiology, Weill Cornell Medicine, New York, USA. Electronic address: keb2012@med.cornell.edu.
Allison D LevyDepartment of Diagnostic Radiology, Weill Cornell Medicine, New York, USA. Electronic address: all2017@med.cornell.edu.
Jessica M PeñaDepartments of Medicine and Radiology, Weill Cornell Medicine, New York, USA. Electronic address: jmp2003@med.cornell.edu.
Cornell University · USWeill Cornell Medicine · US

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
NCATS NIH HHS UL1 TR001873NCATS NIH HHS UL1 TR002384
6 · The paper itself

Abstract

purposeBreast arterial calcifications (BAC) are incidentally observed on mammograms, yet their implications remain unclear. We investigated lifestyle, reproductive, and cardiovascular determinants of BAC in women undergoing mammography screening. Further, we investigated the relationship between BAC, coronary arterial calcifications (CAC) and estimated 10-year atherosclerotic cardiovascular (ASCVD) risk.

methodsIn this cross-sectional study, we obtained reproductive history and CVD risk factors from 215 women aged 18 or older who underwent mammography and cardiac computed tomographic angiography (CCTA) within a 2-year period between 2007 and 2017 at hospital. BAC was categorized as binary (present/absent) and semi-quantitatively (mild, moderate, severe). CAC was determined using the Agatston method and recorded as binary (present/absent). Adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated, accounting for age as a confounding factor. ASCVD risk over a 10-year period was calculated using the Pooled Cohort Risk Equations.

resultsOlder age, systolic and diastolic blood pressures, higher parity, and younger age at first birth (≤28 years) were significantly associated with greater odds of BAC. Women with both BAC and CAC had the highest estimated 10-year risk of ASCVD (13.30 %). Those with only BAC (8.80 %), only CAC (5.80 %), and no BAC or CAC (4.40 %) had lower estimated 10-year risks of ASCVD. No association was detected between presence of BAC and CAC.

conclusionsThese findings support the hypothesis that BAC on a screening mammogram may help to identify women at potentially increased risk of future cardiovascular disease without additional cost and radiation exposure.

Indexed as

Breast DiseasesCalcinosisCardiovascular DiseasesCoronary Artery DiseaseVascular CalcificationBreastCross-Sectional StudiesFemaleHumansMammographyRisk FactorsArteriosclerosisBreast arterial calcificationCardiovascular diseaseMammography screening

Identifiers

PMID38582071
PMCPMC11627068
OpenAlexW4392780512

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.