Evidence map›Paper›PMID 38581947›Full record

ArticleBiochemical and biophysical research communications2024

Effects of LP533401 on vascular and bone calcification in hyperlipidemic mice.

Stuti Pradhan, Andy Hon, Yuxuan Xia, Sophia Kalanski, Nora Safvati, Mimi Lu, Linda L Demer, Yin Tintut

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Stuti PradhanDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Andy HonDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Yuxuan XiaDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Sophia KalanskiDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Nora SafvatiDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Mimi LuDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Linda L DemerDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA; Department of Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Yin TintutDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Department of Physiology, University of California, Los Angeles, Los Angeles, CA, USA; Department of Orthopaedic Surgery, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: ytintut@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Role of intermittent activation of parathyroid hormone receptor in exercise-induced vascular calcificationR01HL151391 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEMER, LINDA L., TINTUT, YIN · 2021 to 2024
$2.2M
Serotonin receptor contribution to inflammation-induced calcific aortic valve diseaseR01HL137647 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEMER, LINDA L., TINTUT, YIN · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL137647NHLBI NIH HHS R01 HL151391
6 · The paper itself

Abstract

Peripheral serotonin levels are associated with cardiovascular disease risk. We previously found that serum serotonin levels are higher in hyperlipidemic mice than wild-type mice. Evidence also suggests that serotonin regulates biomineralization, in that serotonin treatment augments TNF-a-induced matrix calcification of aortic valve interstitial cells and that a selective inhibitor of peripheral serotonin, LP533401, rescues bone loss induced by ovariectomy in mice. Thus, in the present study, we examined the effects of LP533401 on both skeletal bone mineral density (BMD) and aortic calcification in both young and older hyperlipidemic mice susceptible to calcific atherosclerosis and bone loss. By serial in vivo microCT imaging, we assessed BMD and aortic calcification of Apoe

Indexed as

AtherosclerosisCalcinosisHyperlipidemiasPyrimidinesVascular CalcificationAnimalsAortic ValveCalcification, PhysiologicFemaleMiceSerotoninLP533401PyrimidinesSerotoninAtherosclerosisBone mineral densityCalcificationSerotonin

Identifiers

PMID38581947
PMCPMC12054358
OpenAlexW4393359347

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.