Evidence map›Paper›PMID 38581751›Full record

ArticleAddictive behaviors2024

Intrinsic connectivity demonstrates a shared role of the posterior cingulate for cue reactivity in both gambling and cocaine use disorders.

Anthony G Vaccaro, Cheryl M Lacadie, Marc N Potenza

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In one paragraph

Article in Addictive behaviors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anthony G VaccaroDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Cheryl M LacadieDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Marc N PotenzaDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Child Study Center, Yale University School of Medicine, New Haven, CT, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Connecticut Council on Problem Gambling, Wethersfield, CT, USA; Connecticut Mental Health Center, New Haven, CT, USA; Wu Tsai Institute, Yale University, New Haven, CT, USA. Electronic address: marc.potenza@yale.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
fMRI of Craving in Addictions: Gender DifferencesR01DA019039 · NIDA · YALE UNIVERSITY · PI POTENZA, MARC N · 2005 to 2009
$1.6M
Functional networks related to cocaine dependence and its treatment and relapseR01DA039136 · NIDA · YALE UNIVERSITY · PI POTENZA, MARC N · 2016 to 2018
$754k
NCATS NIH HHS UL1 TR001863NIDA NIH HHS R01 DA019039NIDA NIH HHS R01 DA039136
6 · The paper itself

Abstract

Cue reactivity is relevant across addictive disorders as a process relevant to maintenance, relapse, and craving. Understanding the neurobiological foundations of cue reactivity across substance and behavioral addictions has important implications for intervention development. The present study used intrinsic connectivity distribution methods to examine functional connectivity during a cue-exposure fMRI task involving gambling, cocaine and sad videos in 22 subjects with gambling disorder, 24 with cocaine use disorder, and 40 healthy comparison subjects. Intrinsic connectivity distribution implicated the posterior cingulate cortex (PCC) at a stringent whole-brain threshold. Post-hoc analyses investigating the nature of the findings indicated that individuals with gambling disorder and cocaine use disorder exhibited decreased connectivity in the posterior cingulate during gambling and cocaine cues, respectively, as compared to other cues and compared to other groups. Brain-related cue reactivity in substance and behavioral addictions involve PCC connectivity in a content-to-disorder specific fashion. The findings suggesting that PCC-related circuitry underlies cue reactivity across substance and behavioral addictions suggests a potential biomarker for targeting in intervention development.

Indexed as

Cocaine-Related DisordersCuesGamblingGyrus CinguliMagnetic Resonance ImagingAdultCase-Control StudiesCravingFemaleHumansMaleMiddle AgedNeural PathwaysYoung AdultAddictive behaviorCocaine use disorderCompulsive behaviorCravingFunctional magnetic resonance imagingGambling disorderImpulsive behaviorPosterior cingulate cortex

Identifiers

PMID38581751
PMCPMC11273263

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.