Lung-derived soluble factors support stemness/plasticity and metastatic behaviour of breast cancer cells via the FGF2-DACH1 axis.

Vasudeva Bhat, Matthew Piaseczny, David Goodale, Urvi Patel, Ashkan Sadri, Alison L Allan

Open access · hybridAbstract read

In one paragraph

Article in Clinical & experimental metastasis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.7field-weighted citation impact, top 32% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

Fraternal cooperation of hierarchical cancer parallels metazoan multicellularity and eusociality.Biological reviews of the Cambridge Philosophical Society · 2026
Review
Premetastatic niche mechanics and organotropism in breast cancer.npj biological physics and mechanics · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Vasudeva BhatLondon Regional Cancer Program, London Health Science Centre, London, ON, N6A 5W9, Canada. vbhat@uwo.ca.

Matthew PiasecznyDepartment of Anatomy & Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A 5C1, Canada.

David GoodaleLondon Regional Cancer Program, London Health Science Centre, London, ON, N6A 5W9, Canada.

Urvi PatelDepartment of Anatomy & Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A 5C1, Canada.

Ashkan SadriDepartment of Anatomy & Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A 5C1, Canada.

Alison L AllanLondon Regional Cancer Program, London Health Science Centre, London, ON, N6A 5W9, Canada.

Western University · CALondon Health Sciences Centre · CA

Funding

London Regional Cancer Program Catalyst Grant LHR F8319U.S. Army Department of Defense Breast Cancer Program BC160912

6 · The paper itself

Abstract

Patients with triple-negative breast cancer (TNBC) have an increased propensity to develop lung metastasis. Our previous studies demonstrated that stem-like ALDH

Indexed as

Fibroblast Growth Factor 2Lung NeoplasmsNeoplastic Stem CellsTriple Negative Breast NeoplasmsAnimalsCell Line, TumorCulture Media, ConditionedFemaleHumansMiceTranscription FactorsTumor MicroenvironmentCulture Media, ConditionedFibroblast Growth Factor 2Transcription FactorsBreast cancerDachshund homolog 1 (DACH1)Fibroblast growth factor 2 (FGF2)Lung metastasisLung microenvironmentStemness/plasticity

Identifiers

PMID38581619

DOI10.1002/jcb.21561

PMCPMC11499378

OpenAlexW4394012741

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.