Evidence map›Paper›PMID 38581545›Full record

ArticleJournal of neurology2024

Peripheral immune profile in drug-naïve dementia with Lewy bodies.

Tadashi Umehara, Masahiro Mimori, Tatsushi Kokubu, Masakazu Ozawa, Tomotaka Shiraishi, Takeo Sato, Asako Onda, Hiromasa Matsuno, Shusaku Omoto, Renpei Sengoku and 3 more

Abstract read
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In one paragraph

Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. HDL cholesterol indicates neurodegenerative vulnerability in dementia with lewy bodies.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Tadashi UmeharaDepartment of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan. tumety@jikei.ac.jp.ORCID http://orcid.org/0000-0003-4156-5617
Masahiro MimoriDepartment of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan.
Tatsushi KokubuDepartment of Neurology, Katsushika Medical Center, The Jikei University School of Medicine, Tokyo, Japan.
Masakazu OzawaDepartment of Neurology, Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan.
Tomotaka ShiraishiDepartment of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan.
Takeo SatoDepartment of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan.
Asako OndaDepartment of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan.
Hiromasa MatsunoDepartment of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan.
Shusaku OmotoDepartment of Neurology, Katsushika Medical Center, The Jikei University School of Medicine, Tokyo, Japan.
Renpei SengokuDepartment of Neurology, Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan.
Hidetomo MurakamiDepartment of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan.
Hisayoshi OkaDepartment of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan.
Yasuyuki IguchiDepartment of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan.
Jikei University School of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccumulating evidence suggests that peripheral inflammation is associated with the pathogenesis of Parkinson's disease (PD). We examined peripheral immune profiles and their association with clinical characteristics in patients with DLB and compared these with values in patients with PD.

methodsWe analyzed peripheral blood from 93 participants (drug-naïve DLB, 31; drug-naïve PD, 31; controls, 31). Absolute leukocyte counts, absolute counts of leukocyte subpopulations, and peripheral blood inflammatory indices such as neutrophil-to-lymphocyte ratio were examined. Associations with clinical characteristics, cardiac sympathetic denervation, and striatal

resultsPatients with DLB had lower absolute lymphocyte and basophil counts than did age-matched controls (both; p < 0.005). Higher basophil counts were marginally associated with higher global cognition (p = 0.054) and were significantly associated with milder motor severity (p = 0.020) and higher striatal

conclusionsAs in patients with PD, the peripheral immune profile is altered in patients with DLB. Some peripheral immune cell counts and inflammatory indices reflect the degree of disease progression. These findings may deepen our knowledge on the role of peripheral inflammation in the pathogenesis of DLB.

Indexed as

Lewy Body DiseaseAgedAged, 80 and overBasophilsFemaleHumansInflammationLeukocyte CountLymphocytesMaleMiddle AgedParkinson DiseaseTropanes2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropaneTropanesBasophil countsDementia with Lewy bodiesLymphocyte countsParkinson’s diseasePeripheral blood inflammatory indicesPeripheral immune cell

Identifiers

PMID38581545
OpenAlexW4394010041

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.