Evidence map›Paper›PMID 38581480›Full record

ArticleEJNMMI research2024

In-vivo inhibition of neutral endopeptidase 1 results in higher absorbed tumor doses of [

Christof Rottenburger, Michael Hentschel, Markus Fürstner, Lisa McDougall, Danijela Kottoros, Felix Kaul, Rosalba Mansi, Melpomeni Fani, A Hans Vija, Roger Schibli and 4 more

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Evaluation of treatment efficacy of theEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Article
  3. The molecular blueprint of targeted radionuclide therapy.Nature reviews. Clinical oncology · 2025
    Review
  4. Review
  5. RM2 and DB15 analogues bearing [EJNMMI radiopharmacy and chemistry · 2025
    Article
  6. First-in-Human Serum Stability Studies of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  7. Radiopharmaceutical formulation and preliminary clinical dosimetry of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Christof RottenburgerDivision of Nuclear Medicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.ORCID http://orcid.org/0000-0003-3338-9959
Michael HentschelDivision of Nuclear Medicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.
Markus FürstnerDivision of Medical Radiation Physics, Department of Radiation Oncology, Bern University Hospital, Bern, Switzerland.
Lisa McDougallDivision of Nuclear Medicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.
Danijela KottorosDivision of Nuclear Medicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.
Felix KaulDivision of Nuclear Medicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.
Rosalba MansiDivision of Radiopharmaceutical Chemistry, University Hospital Basel, Basel, Switzerland.
Melpomeni FaniDivision of Radiopharmaceutical Chemistry, University Hospital Basel, Basel, Switzerland.
A Hans VijaMolecular Imaging, Siemens Medical Solutions USA, Inc., Hoffman Estates, IL, USA.
Roger SchibliDepartment of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH, Zurich, Switzerland.
Susanne GeistlichCenter for Radiopharmaceutical Sciences, Paul Scherrer Institute, Villigen, Switzerland.
Martin BeheCenter for Radiopharmaceutical Sciences, Paul Scherrer Institute, Villigen, Switzerland.
Emanuel R ChristCenter for Neuroendocrine and Endocrine Tumors, University Hospital Basel, Basel, Switzerland.
Damian WildDivision of Nuclear Medicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland. damian.wild@usb.ch.ORCID http://orcid.org/0000-0002-8135-5350
University Hospital of Basel · CHPaul Scherrer Institute · CHUniversity Hospital of Bern · CH

Funding

Swiss Cancer Research Foundation KFS-3170-02-2013
6 · The paper itself

Abstract

backgroundA new generation of radiolabeled minigastrin analogs delivers low radiation doses to kidneys and are considered relatively stable due to less enzymatic degradation. Nevertheless, relatively low tumor radiation doses in patients indicate limited stability in humans. We aimed at evaluating the effect of sacubitril, an inhibitor of the neutral endopeptidase 1, on the stability and absorbed doses to tumors and organs by the cholecystokinin-2 receptor agonist [

resultsPretreatment with Entresto

conclusionsPremedication with Entresto

Indexed as

[177Lu]Lu-PP-FF11NCholecystokinin-2 receptor targetingEndopeptidase inhibitionNeutral endopeptidase 1Peptide receptor radionuclide therapy

Identifiers

PMID38581480
PMCPMC10998826
OpenAlexW4394013763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.