ArticleThe Plant cell2024
The AGAMOUS-LIKE 16-GENERAL REGULATORY FACTOR 1 module regulates axillary bud outgrowth via catabolism of abscisic acid in cucumber.
Article in The Plant cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- MdAGL29 positively regulates MdBRC1/2 and negatively controls shoot branching in apple.Plant cell reports · 2026Article
- Genome-wide characterization of MADS-box genes and their roles in axillary bud development in tobacco.Plant cell reports · 2026Article
- Phytohormones and Shoot Branching: A Mini-Review of Molecular Regulatory Networks and Mechanisms.Plants (Basel, Switzerland) · 2026Review
- Genome-wide characterization of the TCP family in Lagerstroemia and functional analysis of LfiTCP12 uncover its role in shoot branching promotion.Plant cell reports · 2026Article
- Rhizosphere microbiome dynamics and hormonal interactions regulating tiller development in sugarcane cultivars.Scientific reports · 2026Article
- Integrated Phylogenomic and Expression Analyses Reveal Lineage-Specific Loss of the Mβ Subfamily and Regulatory Diversification of MADS-Box Genes in Pepper.Plants (Basel, Switzerland) · 2026Article
- FveDAD2 negatively regulates branch crowns by affecting abscisic acid metabolism through FveHB7 in woodland strawberry.Horticulture research · 2026Article
- Ethylene promotes branch formation but inhibits tendril development in cucumber.Nature communications · 2025Article
- Identification of CsAFP3-like as a novel gene regulating determinate growth of lateral branch in cucumber.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- The CsTIE1-CsAGL16 module regulates lateral branch outgrowth and drought tolerance in cucumber.Horticulture research · 2025Article
- The mutation of ent-kaurenoic acid oxidase, a key enzyme involved in gibberellin biosynthesis, confers a dwarf phenotype to cucumber.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Review
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Authors and funding
17 authors at 2 institutions in 1 country.
Funding
Abstract
Lateral branches are important components of shoot architecture and directly affect crop yield and production cost. Although sporadic studies have implicated abscisic acid (ABA) biosynthesis in axillary bud outgrowth, the function of ABA catabolism and its upstream regulators in shoot branching remain elusive. Here, we showed that the MADS-box transcription factor AGAMOUS-LIKE 16 (CsAGL16) is a positive regulator of axillary bud outgrowth in cucumber (Cucumis sativus). Functional disruption of CsAGL16 led to reduced bud outgrowth, whereas overexpression of CsAGL16 resulted in enhanced branching. CsAGL16 directly binds to the promoter of the ABA 8'-hydroxylase gene CsCYP707A4 and promotes its expression. Loss of CsCYP707A4 function inhibited axillary bud outgrowth and increased ABA levels. Elevated expression of CsCYP707A4 or treatment with an ABA biosynthesis inhibitor largely rescued the Csagl16 mutant phenotype. Moreover, cucumber General Regulatory Factor 1 (CsGRF1) interacts with CsAGL16 and antagonizes CsAGL16-mediated CsCYP707A4 activation. Disruption of CsGRF1 resulted in elongated branches and decreased ABA levels in the axillary buds. The Csagl16 Csgrf1 double mutant exhibited a branching phenotype resembling that of the Csagl16 single mutant. Therefore, our data suggest that the CsAGL16-CsGRF1 module regulates axillary bud outgrowth via CsCYP707A4-mediated ABA catabolism in cucumber. Our findings provide a strategy to manipulate ABA levels in axillary buds during crop breeding to produce desirable branching phenotypes.
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