Evidence map›Paper›PMID 38581346›Full record

ArticleMolecular nutrition & food research2024

Modifying Effects of Genetic Variations on the Association Between Dietary Isothiocyanate Exposure and Non-muscle Invasive Bladder Cancer Prognosis in the Be-Well Study.

Zinian Wang, Marilyn L Kwan, Reina Haque, Prashant K Singh, Maciej Goniewicz, Rachel Pratt, Valerie S Lee, Janise M Roh, Isaac J Ergas, Kimberly L Cannavale and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular nutrition & food research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Zinian WangDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.ORCID 0000-0002-3088-6995
Marilyn L KwanDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Reina HaqueDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.
Prashant K SinghDepartment of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Maciej GoniewiczHealth Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Rachel PrattDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Valerie S LeeDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Janise M RohDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Isaac J ErgasDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Kimberly L CannavaleDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.
Ronald K LooDepartment of Urology, Kaiser Permanente Downey Medical Center, Downey, CA, USA.
David S AaronsonDepartment of Urology, Kaiser Permanente Oakland Medical Center, Oakland, CA, USA.
Charles P QuesenberryDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Yuesheng ZhangDepartment of Pharmacology and Toxicology, and Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA, USA.
Christine B AmbrosoneDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Lawrence H KushiDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Li TangDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.ORCID 0000-0002-6776-1846
Kaiser Permanente · USRoswell Park Comprehensive Cancer Center · USKaiser Permanente Oakland Medical Center · USVirginia Commonwealth University · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
Transcriptomic classification of non-muscle invasive bladder cancer and its clinical and prognostic implicationR01CA257480 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI KWAN, MARILYN L, TANG, LI · 2022 to 2025
$6.5M
Diet and Lifestyle in a Prospective Study of Bladder Cancer SurvivorsR01CA172855 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI KUSHI, LAWRENCE H, KWAN, MARILYN L · 2014 to 2018
$5.0M
Impact of Body Composition and Related Inflammatory and Immune States on Prognosis of Non-Muscle Invasive Bladder CancerU01CA280991 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI Marilyn L Kwan, LI TANG · 2023 to 2026
$3.5M
NCI NIH HHS 3R01CA172855-04S1NCI NIH HHS P30 CA016056NCI NIH HHS P30CA016056NCI NIH HHS R01 CA172855NCI NIH HHS R01CA172855NCI NIH HHS R01 CA257480NCI NIH HHS R01CA257480NCI NIH HHS U01 CA280991NCI NIH HHS U01CA280991
6 · The paper itself

Abstract

scopeDietary isothiocyanate (ITC) exposure from cruciferous vegetable (CV) intake may improve non-muscle invasive bladder cancer (NMIBC) prognosis. This study aims to investigate whether genetic variations in key ITC-metabolizing/functioning genes modify the associations between dietary ITC exposure and NMIBC prognosis outcomes. METHODS AND

resultsIn the Bladder Cancer Epidemiology, Wellness, and Lifestyle Study (Be-Well Study), a prospective cohort of 1472 incident NMIBC patients, dietary ITC exposure is assessed by self-reported CV intake and measured in plasma ITC-albumin adducts. Using Cox proportional hazards regression models, stratified by single nucleotide polymorphisms (SNPs) in nine key ITC-metabolizing/functioning genes, it is calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for recurrence and progression. The rs15561 in N-acetyltransferase 1 (NAT1) is alter the association between CV intake and progression risk. Multiple SNPs in nuclear factor E2-related factor 2 (NRF2) and nuclear factor kappa B (NFκB) are modify the associations between plasma ITC-albumin adduct level and progression risk (p

conclusionDespite that genetic variations in ITC-metabolizing/functioning genes may modify the effect of dietary ITCs on NMIBC prognosis, dietary recommendation of CV consumption may help improve NMIBC survivorship.

Indexed as

DietIsothiocyanatesPolymorphism, Single NucleotideUrinary Bladder NeoplasmsAgedArylamine N-AcetyltransferaseFemaleHumansMaleMiddle AgedNF-E2-Related Factor 2Non-Muscle Invasive Bladder NeoplasmsPrognosisProspective StudiesArylamine N-AcetyltransferaseIsothiocyanatesNFE2L2 protein, humanNF-E2-Related Factor 2cruciferous vegetablesisothiocyanatenon‐muscle invasive bladder cancerprogressionrecurrencesingle nucleotide polymorphisms

Identifiers

PMID38581346
PMCPMC11272391
OpenAlexW4394013802

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.