ArticleBMC women's health2024
Reproductive factors and risk of cardiovascular diseases and all-cause and cardiovascular mortality in American women: NHANES 2003-2018.
Article in BMC women's health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Associations of Reproductive Factors With Hypertension Prevalence and Blood Pressure Levels in Female Nurses: A Cross-Sectional Study.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Associations between female sex-specific risk factors and cardiometabolic multimorbidity: evidence from the UK Biobank cohort study.BMC public health · 2026Article
- The association between serum follicle-stimulating hormone and luteinizing hormone levels and congestive heart failure in postmenopausal women: a cross-sectional study.Scientific reports · 2026Article
- Reproductive lifespan and cardiovascular health in postmenopausal women: a non-linear, behavior-driven association with cross-population validation.Frontiers in medicine · 2026Article
- Does lifestyle explain the relationship between socioeconomic position and multimorbidity of cancer and cardiometabolic diseases? A mediation analysis applied to the European Prospective Investigation into Cancer and Nutrition.Journal of epidemiology and community health · 2025Article
- Menopausal status, transition, and age at menopause with accelerated biological aging across multiple organ systems: findings from two cohort studies.BMC medicine · 2025Article
- Cardiovascular Disease Risk in Women with Menopause.Journal of clinical medicine · 2025Review
- Observational
- Correction: Reproductive factors and risk of cardiovascular diseases and all-cause and cardiovascular mortality in American women: NHANES 2003-2018.BMC women's health · 2025Article
- Association of the time interval between first and last birth with obesity in middle-aged postmenopausal Chinese women: a cross-sectional study in southern China.Frontiers in medicine · 2025Article
- Association Between Reproductive Lifespan and All-Cause and Cardiovascular Mortality in Women Aged 65 Years and Older: A Cohort Study Using NHANES 1999-2018 Data.International journal of women's health · 2025Article
- Exploring the Influence of Age at Menarche on Metabolic Syndrome and Its Components Across Different Women's Birth Cohorts.Endocrinology, diabetes & metabolism · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
backgroundThe evidence regarding the association of reproductive factors with cardiovascular diseases (CVDs) is limited.
aimsTo investigate the relationship of reproductive factors with the risk of CVDs, as well as all-cause and cardiovascular mortality.
methodsThis study included 16,404 adults with reproductive factors from the National Health and Nutrition Examination Survey (NHANES) and followed up until 31 December 2019. Logistic models and restricted cubic spline models were used to assess the association of reproductive factors with CVDs. COX proportional hazards models and restricted cubic spline models, with adjustment for potential confounding, were employed to analyze the relation between reproductive factors and cardiovascular and all-cause death.
resultsThere is a nonlinear relationship between age at menarche and CVDs. Age at menopause ≤ 11(OR 1.36, 95% CI 1.10-1.69) was associated with an increased risk of CVDs compared to ages 12-13 years. Age at Menopause ≤ 44 (OR 1.69, 95% CI 1.40-2.03) was associated with increased CVDs compared to age 35-49 years. Number of pregnancies ≥ 5(OR 1.26, 95% CI 1.02-1.55) was associated with an increased risk of CVDs compared to one pregnancy. In continuous variable COX regression models, a later age at menopause (HR 0.98, 95% CI 0.97-0.99) and a longer reproductive lifespan (HR 0.98, 95% CI 0.97-0.99) were associated with a decreased risk of all-cause death. A later age at menopause (HR 0.98, 95% CI 0.97-0.99) and a longer reproductive lifespan (HR 0.98, 95% CI 0.97-0.99) were associated with a decreased risk of cardiac death.
conclusionsFemale reproductive factors are significant risk factors for CVDs American women.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.