Evidence map›Paper›PMID 38581018›Full record

ArticleBMC biology2024

Bacterial accumulation in intestinal folds induced by physical and biological factors.

Jinyou Yang, Toma Isaka, Kenji Kikuchi, Keiko Numayama-Tsuruta, Takuji Ishikawa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Physics of microbial taxis and behaviours in response to various physical stimuli.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jinyou YangSchool of Intelligent Medicine, China Medical University, Shenyang, 110122, China. jyyang@cmu.edu.cn.ORCID http://orcid.org/0000-0001-6256-1899
Toma IsakaDepartment of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 6-6-01 Aoba, Sendai, 980-8579, Japan.
Kenji KikuchiDepartment of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 6-6-01 Aoba, Sendai, 980-8579, Japan.
Keiko Numayama-TsurutaDepartment of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 6-6-01 Aoba, Sendai, 980-8579, Japan.
Takuji IshikawaDepartment of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 6-6-01 Aoba, Sendai, 980-8579, Japan.

Funding

JSPS KAKENHI 21H04999JSPS KAKENHI 21H05306JSPS KAKENHI 21H05308JSPS KAKENHI 22H01394JSPS KAKENHI 22KF0025JST FOREST JPMJFR2024
6 · The paper itself

Abstract

backgroundThe gut microbiota, vital for host health, influences metabolism, immune function, and development. Understanding the dynamic processes of bacterial accumulation within the gut is crucial, as it is closely related to immune responses, antibiotic resistance, and colorectal cancer. We investigated Escherichia coli behavior and distribution in zebrafish larval intestines, focusing on the gut microenvironment.

resultsWe discovered that E. coli spread was considerably suppressed within the intestinal folds, leading to a strong physical accumulation in the folds. Moreover, a higher concentration of E. coli on the dorsal side than on the ventral side was observed. Our in vitro microfluidic experiments and theoretical analysis revealed that the overall distribution of E. coli in the intestines was established by a combination of physical factor and bacterial taxis.

conclusionsOur findings provide valuable insight into how the intestinal microenvironment affects bacterial motility and accumulation, enhancing our understanding of the behavioral and ecological dynamics of the intestinal microbiota.

Indexed as

Gastrointestinal MicrobiomeIntestinesAnimalsBacteriaBiological FactorsEscherichia coliZebrafishBiological FactorsBacterial accumulationEscherichia coliGut microbiotaMathematical analysisZebrafish intestine

Identifiers

PMID38581018
PMCPMC10998401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.