Evidence map›Paper›PMID 38580946›Full record

ArticleBMC cardiovascular disorders2024

Rationale and design of the SPRING trail: effectivity and safety of Pfo closuRe vs medIcine in alleviatiNg migraine, a multicenter, randomized and open-label trail.

Yang Zi-Yang, Li Hezhi, Luo Dongling, Wang Ximeng, Zhang Caojin, SPRING Investigators

Registry-linked trialOpen access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04946734 (Effectivity and Safety of PFO Closure vs Medicine in Alleviating Migraine （SPRING）), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04946734 phase3active not recruitingnot on this map

Effectivity and Safety of PFO Closure vs Medicine in Alleviating Migraine （SPRING）: a Multicenter, Random, Case Control Study

TypeinterventionalSponsorGuangdong Provincial People's HospitalRan2021 to 2025Enrolled440ConditionsPFO - Patent Foramen Ovale, MigraineArmsPFO closure device, Aspirin and clopidogrel, Triptans
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 12 institutions in 1 country.

Yang Zi-YangGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Zhong Shan Er Road No. 106, Yue Xiu District, Guangzhou, Guangdong, 510080, China.
Li HezhiGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Zhong Shan Er Road No. 106, Yue Xiu District, Guangzhou, Guangdong, 510080, China.
Luo DonglingGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Zhong Shan Er Road No. 106, Yue Xiu District, Guangzhou, Guangdong, 510080, China.
Wang XimengGlobal Health Research Center, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.
Zhang CaojinGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Zhong Shan Er Road No. 106, Yue Xiu District, Guangzhou, Guangdong, 510080, China. gdzcjpaper@163.com.
SPRING Investigators
Guangdong Academy of Medical Sciences · CNSouth China Sea Institute Of Oceanology · CNWuhan University · CNFirst Affiliated Hospital of Guangzhou Medical University · CNXiamen University · CNCentral South University · CNHuizhou Central People's Hospital · CNJiangmen Central Hospital · CNKey Laboratory of Guangdong Province · CNShanxi Cardiovascular Hospital · CNShenZhen People’s Hospital · CNSun Yat-sen University · CN

Funding

Chinese Society of Cardiology CSCF2020B02
6 · The paper itself

Abstract

backgroundMigraine is a leading cause of disability worldwide. Several retrospective studies have suggested that the closure of the Patent Foramen Ovale (PFO) may provide relief from migraines. However, three randomized controlled trials did not meet their primary endpoints regarding migraine cessation, reduction in monthly migraine days, and responder rates.

methodsThe SPRING study is a multicenter, prospective, randomized, and open-label trial designed to compare the effectiveness and safety of PFO closure versus medication in the relief of migraines. The primary endpoint is the total cessation of migraines, as recorded in patient headache diaries during the follow-up period. Additional diagnostic tools include echocardiography with agitated saline contrast, transcranial Doppler, and routine laboratory measurements.

conclusionThe SPRING trial aims to assess the effectiveness and safety of PFO closure versus medication in mitigating migraines in real-world settings. (Clinical Trails ID: NCT04946734).

Indexed as

Foramen Ovale, PatentMigraine DisordersCardiac CatheterizationHumansProspective StudiesRandomized Controlled Trials as TopicRetrospective StudiesTreatment OutcomeMigrainePatent foramen ovaleRandomized clinical trial

Identifiers

PMID38580946
PMCPMC10998302
OpenAlexW4393979156

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.