Evidence map›Paper›PMID 38580870›Full record

ReviewAngiogenesis2024

Navigating tumor angiogenesis: therapeutic perspectives and myeloid cell regulation mechanism.

Fan Yang, Gloria Lee, Yi Fan

Abstract readReview
In one paragraph

Review in Angiogenesis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Fan YangDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, 19104, USA. fanyangforever@gmail.com.
Gloria LeeDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Yi FanDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, 19104, USA. fanyi@upenn.edu.

Funding

American Association for Cancer Research Judah Folkman AwardAmerican Heart Association Innovation Project Award
6 · The paper itself

Abstract

Sustained angiogenesis stands as a hallmark of cancer. The intricate vascular tumor microenvironment fuels cancer progression and metastasis, fosters therapy resistance, and facilitates immune evasion. Therapeutic strategies targeting tumor vasculature have emerged as transformative for cancer treatment, encompassing anti-angiogenesis, vessel normalization, and endothelial reprogramming. Growing evidence suggests the dynamic regulation of tumor angiogenesis by infiltrating myeloid cells, such as macrophages, myeloid-derived suppressor cells (MDSCs), and neutrophils. Understanding these regulatory mechanisms is pivotal in paving the way for successful vasculature-targeted cancer treatments. Therapeutic interventions aimed to disrupt myeloid cell-mediated tumor angiogenesis may reshape tumor microenvironment and overcome tumor resistance to radio/chemotherapy and immunotherapy.

Indexed as

Myeloid CellsNeoplasmsNeovascularization, PathologicTumor MicroenvironmentAngiogenesisAnimalsHumansMyeloid-Derived Suppressor CellsAnti-angiogenic therapyEndothelial reprogrammingImmunotherapyMacrophagesMDSCsNeutrophilsRadiochemotherapyTherapy resistanceTumor angiogenesisVessel normalization

Identifiers

PMID38580870
PMCPMC11303583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.