Evidence map›Paper›PMID 38580843›Full record

ArticleCommunications biology2024

Catalytic-dependent and -independent roles of TET3 in the regulation of specific genetic programs during neuroectoderm specification.

Harmony C Ketchum, Masako Suzuki, Meelad M Dawlaty

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Harmony C KetchumRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York, USA.
Masako SuzukiDepartment of Nutrition, Texas A&M University, College Station, Texas, USA.ORCID 0000-0003-0605-9225
Meelad M DawlatyRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York, USA. meelad.dawlaty@einsteinmed.edu.ORCID 0000-0003-3121-2500
Albert Einstein College of Medicine · USTexas A&M University · US

Funding

TRAINING PROGRAM IN CELLULAR &MOLEC. BIOLOGY &GENETICST32GM007491 · NIGMS · YESHIVA UNIVERSITY · PI QUERY, CHARLES C · 1985 to 2021
$17.0M
SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SOPHIE MOLHOLM, Steven Upshaw Walkley · 2021 to 2026
$7.0M
Dissecting the canonical and non-canonical functions of Tet2 in hematopoietic stem cells and hematologic disordersR01HL148852 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Meelad Dawlaty, Keisuke Ito · 2019 to 2026
$4.4M
Role of Tet proteins in epigenetic regulation of embryonic stem cell biologyR01GM122839 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DAWLATY, MEELAD · 2018 to 2022
$1.8M
NHLBI NIH HHS R01 HL148852NICHD NIH HHS P50 HD105352NIGMS NIH HHS R01 GM122839NIGMS NIH HHS T32 GM007491
6 · The paper itself

Abstract

The ten-eleven-translocation family of proteins (TET1/2/3) are epigenetic regulators of gene expression. They regulate genes by promoting DNA demethylation (i.e., catalytic activity) and by partnering with regulatory proteins (i.e., non-catalytic functions). Unlike Tet1 and Tet2, Tet3 is not expressed in mouse embryonic stem cells (ESCs) but is induced upon ESC differentiation. However, the significance of its dual roles in lineage specification is less defined. By generating TET3 catalytic-mutant (Tet3

Indexed as

DioxygenasesAnimalsCell DifferentiationDNA-Binding ProteinsDNA MethylationMiceNeural PlateDioxygenasesDNA-Binding ProteinsTet3 protein, mouse

Identifiers

PMID38580843
PMCPMC10997653
OpenAlexW4393972391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.