Evidence map›Paper›PMID 38580775›Full record

ArticleThe EMBO journal2024

A subset of megakaryocytes regulates development of hematopoietic stem cell precursors.

Wenlang Lan, Jinping Li, Zehua Ye, Yumin Liu, Sifan Luo, Xun Lu, Zhan Cao, Yifan Chen, Hongtian Chen, Zhuan Li

Abstract read
In one paragraph

Article in The EMBO journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Versatility of megakaryocytes in homeostasis and disease.Blood science (Baltimore, Md.) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wenlang Lan *Key Laboratory of Functional Proteomics of Guangdong Province, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.ORCID http://orcid.org/0009-0008-6870-1133
Jinping Li *Key Laboratory of Functional Proteomics of Guangdong Province, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.ORCID http://orcid.org/0009-0002-2261-3484
Zehua Ye *Key Laboratory of Functional Proteomics of Guangdong Province, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.ORCID http://orcid.org/0000-0002-3958-0247
Yumin LiuKey Laboratory of Functional Proteomics of Guangdong Province, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.ORCID http://orcid.org/0009-0007-8408-0659
Sifan LuoKey Laboratory of Functional Proteomics of Guangdong Province, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.ORCID http://orcid.org/0009-0008-4510-5726
Xun LuKey Laboratory of Functional Proteomics of Guangdong Province, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.ORCID http://orcid.org/0009-0003-3614-6327
Zhan CaoKey Laboratory of Functional Proteomics of Guangdong Province, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.ORCID http://orcid.org/0009-0000-8956-1354
Yifan ChenKey Laboratory of Functional Proteomics of Guangdong Province, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Hongtian ChenKey Laboratory of Functional Proteomics of Guangdong Province, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.ORCID http://orcid.org/0000-0001-6792-3326
Zhuan LiKey Laboratory of Functional Proteomics of Guangdong Province, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. zhuanli2018@smu.edu.cn.ORCID http://orcid.org/0000-0002-1843-6860

Funding

MOST | National Key Research and Development Program of China (NKPs) 2019YFA0111100MOST | National Key Research and Development Program of China (NKPs) 2019YFA0801802MOST | NSFC | National Natural Science Foundation of China-China Academy of General Technology Joint Fund for Basic Research (NSFC-) 82270119
6 · The paper itself

Abstract

Understanding the regulatory mechanisms facilitating hematopoietic stem cell (HSC) specification during embryogenesis is important for the generation of HSCs in vitro. Megakaryocyte emerged from the yolk sac and produce platelets, which are involved in multiple biological processes, such as preventing hemorrhage. However, whether megakaryocytes regulate HSC development in the embryonic aorta-gonad-mesonephros (AGM) region is unclear. Here, we use platelet factor 4 (PF4)-Cre;Rosa-tdTomato

Indexed as

Hematopoietic Stem CellsMegakaryocytesAnimalsCell DifferentiationCoculture TechniquesEndothelial CellsHematopoiesisMesonephrosMiceEndothelial to Hematopoietic TransitionHematopoietic PrecursorsHematopoietic Stem Cell DevelopmentMegakaryocytesTNFSF14

Identifiers

PMID38580775
PMCPMC11065989

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.