Evidence map›Paper›PMID 38580167›Full record

ArticleBiochemical pharmacology2024

Tabernanthalog and ibogainalog inhibit the α7 and α9α10 nicotinic acetylcholine receptors via different mechanisms and with higher potency than the GABA

Han-Shen Tae, Marcelo O Ortells, Arsalan Yousuf, Sophia Q Xu, Gustav Akk, David J Adams, Hugo R Arias

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
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  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Han-Shen TaeMolecular Horizons/Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia. Electronic address: hstae@uow.edu.au.
Marcelo O OrtellsFacultad de Medicina, Universidad de Morón, and CONICET, Morón, Argentina.
Arsalan YousufMolecular Horizons/Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia.
Sophia Q XuDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.
Gustav AkkDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA; The Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, MO, USA.
David J AdamsMolecular Horizons/Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia.
Hugo R AriasDepartment of Pharmacology and Physiology, Oklahoma State University College of Osteopathic Medicine, Tahlequah, OK, USA.
University of Wollongong · AUWashington University in St. Louis · USConsejo Nacional de Investigaciones Científicas y Técnicas · AROklahoma State University Medical Center · US

Funding

GABAA receptors: function, physiology and involvement in anesthesiaR35GM140947 · NIGMS · WASHINGTON UNIVERSITY · PI AKK, GUSTAV · 2021 to 2025
$1.8M
NIGMS NIH HHS R35 GM140947
6 · The paper itself

Abstract

In this study, we have investigated the pharmacological activity and structural interaction of two novel psychoplastogens, tabernanthalog (TBG) and ibogainalog (IBG) at heterologously-expressed rat (r) and human (h) nicotinic acetylcholine receptors (nAChRs), the rα1β2γ2L γ-aminobutyric acid type A receptor (GABA

Indexed as

Receptors, Nicotinicalpha7 Nicotinic Acetylcholine ReceptorAnimalsgamma-Aminobutyric AcidHumansMolecular Docking SimulationRatsReceptors, GABA-Aalpha7 Nicotinic Acetylcholine Receptorgamma-Aminobutyric AcidReceptors, GABA-AReceptors, NicotinicCa(V)2.2 channelGABA(A) receptorIbogainalogNicotinic acetylcholine receptorPsychoplastogensTabernanthalog

Identifiers

PMID38580167
PMCPMC11151864
OpenAlexW4394019234

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.